Document Detail


Chromatin Structure and Organization: The Relation with Gene Expression During Development and Disease.
MedLine Citation:
PMID:  23150259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The elementary level of chromatin fiber, namely the nucleofilament, is known to undergo a hierarchical compaction leading to local chromatin loops, then chromatin domains and ultimately chromosome territories. These successive folding levels rely on the formation of chromatin loops ranging from few kb to some Mb. In addition to a packaging and structural role, the high-order organization of genomes functionally impacts on gene expression program. This review summarises to which extent each level of chromatin compaction does affect gene regulation. In addition, we point out the structural and functional changes observed in diseases. Emphasis will be mainly placed on the large-scale organization of the chromatin.
Authors:
Benoît Moindrot; Philippe Bouvet; Fabien Mongelard
Related Documents :
24194949 - Overexpression of a cotton gene that encodes a putative transcription factor of ap2/ere...
24950439 - Rna interference of 1-aminocyclopropane-1-carboxylic acid oxidase (aco1 and aco2) genes...
23775819 - Molecular profiling of stroma identifies osteopontin as an independent predictor of poo...
23719559 - Gut microbiota after gastric bypass in human obesity: increased richness and associatio...
24390279 - Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic aav v...
23266949 - In planta stage-specific fungal gene profiling elucidates the molecular strategies of f...
11929539 - Resveratrol acts as a natural profungicide and induces self-intoxication by a specific ...
16939499 - Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line hepg...
19777229 - Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthe...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  61     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  373-396     Citation Subset:  -    
Affiliation:
Laboratoire Joliot-Curie, Centre National de la Recherche Scientifique (CNRS)/Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie, 69007, Lyon, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View.
Next Document:  Epigenetic Regulation of Cancer Stem Cell Gene Expression.