Document Detail

Chromaffin Cells of the Adrenal Gland in the Beagle Dog.
MedLine Citation:
PMID:  22762393     Owner:  NLM     Status:  Publisher    
The distribution of adrenal chromaffin cells in the control beagle dog was investigated. The presence of chromaffin cells in the adrenal medulla, three zones of the adrenal cortex and capsule was identified by staining with H&E, chromium salts and TH (tyrosine hydroxylase) antibody. With H&E stain, there are morphological differences among the chromaffin cells in the medulla, cortex and capsule. In addition, the number of the capsular chromaffin cells was statistically significantly decreased in the 8-9, 11-12 and 15-16 month age groups compared with the 5-6 month age group. Both medullary and extra-medullary chromaffin cells contained catecholamines, demonstrated via special staining for chromium salts. TH is the first enzyme in catecholamine biosynthesis; it is a useful maker for all cells involved with catecholamine biosynthesis including chromaffin cells. TH antibody confirmed that the extra-medullary cells were chromaffin cells. Terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay for detecting the apoptotic signalling identified the apoptosis of the chromaffin cells in the capsule.
S Qiu; Y Du; L Wang; C Hu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-4
Journal Detail:
Title:  Anatomia, histologia, embryologia     Volume:  -     ISSN:  1439-0264     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704218     Medline TA:  Anat Histol Embryol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Verlag GmbH.
Department of Toxicologic Pathology, National Chengdu Center for Safety Evaluation of Drugs, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, Chengdu, Sichuan, China.
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