Document Detail


Choroidal thickness in retinal pigment epithelial tear as measured by spectral domain optical coherence tomography.
MedLine Citation:
PMID:  23764968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the choroidal thickness with spectral domain optical coherence tomography in subjects with retinal pigment epithelial (RPE) tear compared with the choroidal thickness of their fellow eye.
METHODS: For this cross-sectional investigation, seven eyes of seven patients with neovascular age-related macular degeneration and RPE tear in one eye imaged with spectral domain optical coherence tomography were identified. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500 μm intervals up to 2,500 μm temporal and nasal to the fovea in both the eye with the RPE tear and the eye with intact RPE. All measurements were performed by two independent observers and averaged for the purpose of the analysis. Measurements were compared using paired t-test.
RESULTS: The average age of patients was 79 years (range, 66-88 years). All subjects had dome-shaped pigment epithelial detachments before RPE tear and no dome-shaped pigment epithelial detachments in the unaffected eye. Average subfoveal choroidal thickness in the eye with the RPE tear was 154.9 ± 10.1 µm. Average subfoveal choroidal thickness in the eye with intact RPE was 212.9 ± 10.6 µm (P = 0.035).
CONCLUSION: There is a significant decrease in subfoveal choroidal thickness in the subjects with RPE tear compared with their fellow eye with intact RPE. It is unclear if this thinning is a consequence of or precedes the RPE tear. Further studies are necessary to prospectively follow choroidal thickness in subjects with dome-shaped pigment epithelial detachments.
Authors:
Kavita V Bhavsar; Lauren Branchini; Heeral Shah; Caio V Regatieri; Jay S Duker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  34     ISSN:  1539-2864     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-23     Completed Date:  2014-04-16     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Choroid / pathology*
Cross-Sectional Studies
Female
Humans
Male
Retinal Perforations / diagnosis,  etiology*
Retinal Pigment Epithelium / pathology
Tomography, Optical Coherence*
Wet Macular Degeneration / complications*
Grant Support
ID/Acronym/Agency:
R01 EY013516/EY/NEI NIH HHS; R01-EY013516-07/EY/NEI NIH HHS; R01-EY11289-23/EY/NEI NIH HHS; R01-EY13178-07/EY/NEI NIH HHS
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