| Choroidal neovascular membrane in persistent fetal vasculature syndrome managed with intravitreal pegaptanib sodium in an infant. | |
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MedLine Citation:
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PMID: 20419850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to report the successful management of a case of choroidal neovascular membrane secondary to persistent fetal vasculature syndrome in an infant using intravitreal pegaptanib sodium (Macugen). METHODS: A 14-month-old male infant developed a peripapillary choroidal neovascular membrane 10 months after lens-sparing vitrectomy that he underwent for persistent fetal vasculature syndrome and confirmed on angiography and optical coherence tomography. A single dose of intravitreal pegaptanib sodium (0.3 mg) was administered after informed consent was obtained. Angiography and optical coherence tomography scans were performed at 6 and 14 weeks after the injection to determine the result. RESULTS: Six weeks after the single injection, the lesion reduced in size and exhibited less leakage on angiography. At 14 weeks, leakage was absent, and the lesion had involuted. CONCLUSION: Choroidal neovascular membrane in a case of persistent fetal vasculature syndrome is rare. This report shows that intravitreal pegaptanib sodium is highly effective in treating this lesion even in an infant. |
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Authors:
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Anand Vinekar; Newman Sund; Polly Quiram; Antonio Capone |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Retina (Philadelphia, Pa.) Volume: 30 ISSN: 1539-2864 ISO Abbreviation: Retina (Philadelphia, Pa.) Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309919 Medline TA: Retina Country: United States |
Other Details:
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Languages: eng Pagination: S41-4 Citation Subset: IM |
Affiliation:
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Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, Karnataka, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aptamers, Nucleotide
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therapeutic use* Choroidal Neovascularization / diagnosis, drug therapy*, etiology, physiopathology Fluorescein Angiography Humans Infant Injections Male Persistent Hyperplastic Primary Vitreous / surgery* Postoperative Complications* Tomography, Optical Coherence Vascular Endothelial Growth Factor A / antagonists & inhibitors Visual Acuity / physiology Vitrectomy* Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Vascular Endothelial Growth Factor A; 0/pegaptanib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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