| Choroidal blood flow regulation after posture change or isometric exercise in men with obstructive sleep apnea syndrome. | |
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MedLine Citation:
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PMID: 22025580 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives:Obstructive sleep apnea (OSA) syndrome generates hypertension, atherosclerosis, as well as endothelial and autonomic dysfunction, which may mutually interact with ocular vascular regulation. Exercise and posture changes can be used to manipulate blood pressure and /or ocular perfusion pressure (OPP). We hypothesized that choroidal vascular reactivity in response to isometric exercise and posture changes could be altered in OSA patients.Methods:Healthy men were matched 1:1 for body mass index, sex, and age with patients with newly diagnosed OSA without cardiovascular co-morbidities. All subjects underwent sleep studies and cardiovascular phenotyping (24-h blood pressure monitoring, arterial stiffness measurements, and cardiac and carotid echography). Choroidal reactivity was assessed by laser Doppler flowmetry, which measured subfoveal choroidal blood flow.Results:During exercise, blood pressure parameters increased significantly within the same range, with a similar profile over time in OSA and controls. A significant linear relationship (p=0.0003) was noted between choroidal vascular resistance and the OPP changes during exercise in OSA and controls. From the sitting to the supine position, a significant decrease in mean arterial pressure occurred in both groups (10.9-13.4%, p<0.001). In both populations, no significant change in choroidal blood flow or vascular resistance was found during the posture change. Choroidal blood flow responses to exercise and posture changes were unchanged after 6-9 months of CPAP treatment.Conclusions:This study strongly suggests that the regulation of choroidal blood flow, which depends on the ortho- and parasympathetic systems, is unaltered in men suffering from OSA with no co-morbidities. |
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Authors:
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Hafid Khayi; Jean-Louis Pepin; Martial H Geiser; Matthieu Tonini; Renaud Tamisier; Elisabeth Renard; Jean-Philippe Baguet; Patrick Levy; Jean-Paul Romanet; Christophe Chiquet |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-24 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Ophthalmology, CHU de Grenoble, F38043, university hospital, universitÈ Joseph Fourier- Grenoble 1, F38041, Grenoble, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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