Document Detail

Choroidal blood flow regulation after posture change or isometric exercise in men with obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  22025580     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Obstructive sleep apnea (OSA) syndrome generates hypertension, atherosclerosis, and endothelial and autonomic dysfunction, which may mutually interact with ocular vascular regulation. Exercise and posture changes can be used to manipulate blood pressure, ocular perfusion pressure (OPP), or both. It was hypothesized that choroidal vascular reactivity in response to isometric exercise and posture changes could be altered in OSA patients.
METHODS: Healthy men were matched 1:1 for body mass index, sex, and age with patients with newly diagnosed OSA without cardiovascular comorbidities. All subjects underwent sleep studies and cardiovascular phenotyping (24-hour blood pressure monitoring, arterial stiffness measurements, and cardiac and carotid echography). Choroidal reactivity was assessed by laser Doppler flowmetry, which measured subfoveal choroidal blood flow.
RESULTS: During exercise, blood pressure parameters increased significantly within the same range, with a similar profile over time in OSA patients and control subjects. A significant linear relationship (P = 0.0003) was noted between choroidal vascular resistance and the OPP changes during exercise in OSA patients and control subjects. From the sitting to the supine position, a significant decrease in mean arterial pressure occurred in both groups (10.9%-13.4%; P < 0.001). In both populations, no significant change in choroidal blood flow or vascular resistance was found during the posture change. Choroidal blood flow responses to exercise and posture changes were unchanged after 6 to 9 months of continuous positive airway pressure treatment.
CONCLUSIONS: This study strongly suggests that the regulation of choroidal blood flow, which depends on the orthosympathetic and parasympathetic systems, is unaltered in men with OSA who have no comorbidities.
Hafid Khayi; Jean-Louis Pepin; Martial H Geiser; Matthieu Tonini; Renaud Tamisier; Elisabeth Renard; Jean-Philippe Baguet; Patrick Levy; Jean-Paul Romanet; Christophe Chiquet
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-12-16
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-02-03     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9489-96     Citation Subset:  IM    
Department of Ophthalmology, University Hospital, Université Joseph Fourier, Grenoble, France.
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MeSH Terms
Analysis of Variance
Blood Flow Velocity / physiology
Blood Pressure / physiology
Choroid / blood supply*,  physiopathology
Continuous Positive Airway Pressure
Cross-Over Studies
Double-Blind Method
Exercise / physiology*
Heart Rate / physiology
Intraocular Pressure / physiology
Middle Aged
Posture / physiology*
Prospective Studies
Regional Blood Flow / physiology
Sleep Apnea, Obstructive / physiopathology*,  therapy
Vascular Resistance / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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