| Choroidal blood flow after isovolemic hemodilution in an eye with retinal vein occlusion and the contralateral healthy eye. | |
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MedLine Citation:
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PMID: 20175271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effect of hemodilution on subfoveal choroidal blood flow in the human eye with or without retinal vein occlusion. METHODS: Choroidal blood flow was measured using laser Doppler flowmetry in 28 patients with retinal vein occlusion in 1 eye. Isovolemic hemodilution was performed when hematocrit was >35%. Laser Doppler flowmetry parameters, velocity, volume, and flow were measured in both eyes in 4 sessions: 1 hour before and 1 hour after the first hemodilution on Day 1 and Day 7. RESULTS: Hematocrit decreased significantly by 23.7%, 19.8%, and 16.1% in the first hour, on the first day, and the seventh day after hemodilution, respectively (P < 0.001). The ocular perfusion pressure of the healthy eye and the eye with retinal vein occlusion decreased by 7.7% and 7.2% after 1 hour and by 5.3% and 4.7% 1 day after hemodilution, respectively (P < 0.01). After hemodilution, subfoveal choroidal blood velocity, volume, flow, and vascular resistance did not significantly change in either eye. CONCLUSION: Laser Doppler flowmetry measurement in the subfoveal choroid is a feasible technique for blood flow assessment in patients with retinal vein occlusion. A substantial change of hematocrit after isovolemic hemodilution does not lead to a significant change in choroidal blood flow. Vascular regulation is expected to keep blood flow constant and needs to be further explored. |
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Authors:
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Christophe Chiquet; Matthieu Tonini; Philippe Drillat; Viviane Vinh Moreau Gaudry; Jean-Paul Romanet; Martial Henri Geiser |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Retina (Philadelphia, Pa.) Volume: 30 ISSN: 1539-2864 ISO Abbreviation: Retina (Philadelphia, Pa.) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309919 Medline TA: Retina Country: United States |
Other Details:
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Languages: eng Pagination: 275-80 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University Hospital of Grenoble, Joseph Fourier University, Grenoble, France. cchiquet@chu-grenoble.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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physiology Blood Pressure / physiology Choroid / blood supply* Female Fluorescein Angiography Heart Rate / physiology Hematocrit Hemodilution* Humans Intraocular Pressure / physiology Laser-Doppler Flowmetry Male Middle Aged Ocular Physiological Phenomena Pilot Projects Regional Blood Flow Retinal Vein Occlusion / physiopathology* Tomography, Optical Coherence Visual Acuity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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