Document Detail

Chorionic villus sampling and transverse digital deficiencies: evidence for anatomic and gestational-age specificity of the digital deficiencies in two studies.
MedLine Citation:
PMID:  8882399     Owner:  NLM     Status:  MEDLINE    
Several but not all studies indicate that chorionic villus sampling (CVS) is associated with an increased risk for transverse limb deficiencies, including digital deficiencies. It has been suggested that variations in results regarding the transverse digital deficiencies (TDDs) may be due to the use of different classification criteria. We present the combined analysis of two case-control studies, the U.S. Multistate CVS (US) study and the Italian Multicentric Birth Defects (IP-IMC) study, using two different definitions of TDDs. We compared the frequency of CVS exposure in control infants with that among those infants with any number of affected digits (any TDD), and those with all five digits of at least one limb affected (extensive TDDs). The estimated relative risk (RR) for any TDD following CVS was 10.6 (IPIMC) and 6.6 (US). For the extensive TDDs, the RR was 30.5 (IPIMC) and 10.7 (US). In both studies, extensive TDDs were less than 25% of all TDDs. Compared to all TDDs, extensive TDDs were more likely to occur after CVS performed earlier in the first trimester (before 10-11 weeks' gestation). These findings suggest a relationship between the timing of CVS and the severity of TDDs; indicate that using a restrictive definition of TDDs (all five digits affected) may limit the ability to evaluate the association between CVS and TDDs in populations in whom CVS is usually performed at or after 10 weeks' gestation; and highlight the necessity to consider gestational age in any evaluation of the relative risk for limb deficiencies associated with CVS.
L D Botto; R S Olney; P Mastroiacovo; M J Khoury; C A Moore; C J Alo; P Costa; L D Edmonds; T J Flood; J A Harris; H L Howe; C L Olsen; S R Panny; G M Shaw
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of medical genetics     Volume:  62     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-13     Completed Date:  1996-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
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MeSH Terms
Chorionic Villi Sampling*
Gestational Age
Comment In:
Am J Med Genet. 1996 Dec 30;66(4):471-4   [PMID:  8989471 ]

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