Document Detail

Chorionic villus sampling safety. Report of World Health Organization/EURO meeting in association with the Seventh International Conference on Early Prenatal Diagnosis of Genetic Diseases, Tel-Aviv, Israel, May 21, 1994.
MedLine Citation:
PMID:  8633647     Owner:  NLM     Status:  MEDLINE    
Accumulated experience of 138,996 cases of chorionic villus sampling shows that chorionic villus sampling is a safe procedure with an associated fetal loss rate comparable to that of amniocentesis. The chorionic villus sampling registry shows that chorionic villus sampling is currently performed primarily between 9 and 12 weeks' gestation and carried no increased risk of limb reduction defects: the overall incidence of limb reduction defects after chorionic villus sampling is 5.2 to 5.7 per 10,000, compared with 4.8 to 5.97 per 10,000 in the general population. Analysis of the pattern distribution of limb defects after chorionic villus sampling revealed no difference from the pattern in the general population. This applies specifically to transverse limb defects. Together with the overall incidence of limb reduction defects, these data provide no evidence for any risk for congenital malformation determined by chorionic villus sampling. Because chorionic villus sampling is currently performed generally after 8 completed weeks of pregnancy, few data are available for analysis of complications related to earlier procedures. Avoiding early chorionic villus sampling also excludes sampling in cases of early fetal death, which can be diagnosed reliably by ultrasonography at 9 weeks of pregnancy.
A Kuliev; L Jackson; U Froster; B Brambati; J L Simpson; Y Verlinsky; N Ginsberg; S Smidt-Jensen; H Zakut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  174     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-07-03     Completed Date:  1996-07-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  807-11     Citation Subset:  AIM; IM    
World Health Organization Collaborating Center for Prevention of Genetic Disorders, Chicago, IL 60657, USA.
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MeSH Terms
Chorionic Villi Sampling* / adverse effects
Congenital Abnormalities / epidemiology,  etiology
Congresses as Topic
Fetal Death / epidemiology,  etiology
Fetal Diseases / diagnosis*
Genetic Diseases, Inborn / diagnosis*
Genetic Testing
Limb Deformities, Congenital
Prenatal Diagnosis*
Prospective Studies
Risk Factors
World Health Organization

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