Document Detail


Chorionic villus sampling in continuing pregnancies. II. Cytogenetic reliability.
MedLine Citation:
PMID:  3013009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytogenetic analysis was performed on 103 chorionic villus samples. Analysis of the 103 samples revealed six abnormalities. In three of the six the abnormalities were confirmed in fetal or neonatal tissue (47,XY, + 13; 46,XY, t(13q13q); 45,X). In three samples the abnormalities detected were not confirmed; in two of the three the abnormalities were detected only in long-term cultures, whereas in the other samples the abnormality was restricted to direct analysis of the villi after overnight incubation. Our initial experience leads us to conclude that certain abnormalities in chorionic villus sampling may not be indicative of fetal abnormalities; 45,X/46,XX or 45,X/46,XY mosaicism is such a complement. Discrepancies between cytogenetic analysis of intact villi processed soon after sampling and of cells grown in culture can be managed by adhering to several suggested guidelines and by liberal use of confirmatory amniocentesis.
Authors:
A O Martin; J L Simpson; B J Rosinsky; S Elias
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  154     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-10     Completed Date:  1986-07-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1353-62     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Amniocentesis
Aneuploidy
Cells, Cultured
Chorionic Villi / ultrastructure*
Chromosome Aberrations*
Edetic Acid
Female
Humans
Karyotyping
Microbial Collagenase
Mitotic Index
Mosaicism
Pregnancy
Prenatal Diagnosis / methods*
Sex Determination (Analysis)*
Translocation, Genetic
Trypsin
Grant Support
ID/Acronym/Agency:
HD 02840/HD/NICHD NIH HHS; HD 19866/HD/NICHD NIH HHS; HD 52903/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
60-00-4/Edetic Acid; EC 3.4.21.4/Trypsin; EC 3.4.24.3/Microbial Collagenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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