Document Detail

Chorionic villus sampling for first-trimester prenatal diagnosis: Northwestern University program.
MedLine Citation:
PMID:  3890545     Owner:  NLM     Status:  MEDLINE    
We present our initial experience in developing a chorionic villus sampling program at Northwestern University. In phase 1, we performed chorionic villus sampling in 58 patients prior to elective first-trimester abortion, assessing the reliability and reproducibility of obtaining adequate villus samples and performing cytogenetic analysis by means of both the direct and culture methods. Specimens were categorized according to quality: class I, multiple identifiable villi (n = 20); class II, few villi or villi mixed with decidua (n = 15); class III, no villi (n = 23). There was a positive trend between operator experience, amount of villi obtained, and quality of cytogenetic preparations. In March, 1984, we received Institutional Review Board approval to perform chorionic villus sampling in continuing pregnancies (phase 2). Among the first 20 cases we found two abnormalities (47,XY, + 13; 45,X). The remaining 18 pregnancies were continuing. Recommendations are made for developing a chorionic villus sampling program.
S Elias; J L Simpson; A O Martin; R E Sabbagha; A B Gerbie; L G Keith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  152     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-03     Completed Date:  1985-07-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-13     Citation Subset:  AIM; IM    
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MeSH Terms
Catheterization / methods
Cells, Cultured
Chorionic Villi / cytology*
Chromosome Aberrations / diagnosis*
Chromosome Banding
Chromosome Disorders
Genetic Testing / methods*
Pregnancy Trimester, First
Prenatal Diagnosis / methods*
Ultrasonography / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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