Document Detail

Chorionic villus sampling: experience of the first 1000 cases.
MedLine Citation:
PMID:  3717235     Owner:  NLM     Status:  MEDLINE    
Chorionic villus sampling has become widely accepted as a first-trimester alternative to amniocentesis for the prenatal detection of genetic disorders. Our experience with 1000 consecutive cases suggests that spontaneous abortion following the procedure is related to the gestational age at which it is performed, and the rate is acceptably low (3.8%) when the procedure is performed from the ninth through the eleventh menstrual week. Later complications include chorioamnionitis (0.6%) and delayed rupture of membranes and/or oligohydramnios (0.8%). A discrepancy between the villus karyotype and that of the fetus was found in 1.7% of cases and most commonly consisted of mosaicism in the villus sample for a chromosomal abnormality that was not found in fetal samples. We conclude that although chorionic villus sampling appears to be an acceptably safe and reliable procedure, further investigation is needed before this first-trimester technique is widely utilized as an alternative to amniocentesis.
W A Hogge; S A Schonberg; M S Golbus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  154     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-10     Completed Date:  1986-07-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1249-52     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Spontaneous / etiology
Abortion, Therapeutic
Chorionic Villi / ultrastructure*
Chromosome Aberrations*
Congenital Abnormalities / diagnosis*
Diagnostic Errors
Fetal Diseases / etiology
Fetal Membranes, Premature Rupture / etiology
Pregnancy Trimester, First
Prenatal Diagnosis / adverse effects,  methods*

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