| Chorionic villus sampling: experience of the first 1000 cases. | |
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MedLine Citation:
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PMID: 3717235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chorionic villus sampling has become widely accepted as a first-trimester alternative to amniocentesis for the prenatal detection of genetic disorders. Our experience with 1000 consecutive cases suggests that spontaneous abortion following the procedure is related to the gestational age at which it is performed, and the rate is acceptably low (3.8%) when the procedure is performed from the ninth through the eleventh menstrual week. Later complications include chorioamnionitis (0.6%) and delayed rupture of membranes and/or oligohydramnios (0.8%). A discrepancy between the villus karyotype and that of the fetus was found in 1.7% of cases and most commonly consisted of mosaicism in the villus sample for a chromosomal abnormality that was not found in fetal samples. We conclude that although chorionic villus sampling appears to be an acceptably safe and reliable procedure, further investigation is needed before this first-trimester technique is widely utilized as an alternative to amniocentesis. |
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Authors:
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W A Hogge; S A Schonberg; M S Golbus |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 154 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-07-10 Completed Date: 1986-07-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1249-52 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology Abortion, Therapeutic Chorionic Villi / ultrastructure* Chromosome Aberrations* Congenital Abnormalities / diagnosis* Diagnostic Errors Female Fetal Diseases / etiology Fetal Membranes, Premature Rupture / etiology Humans Karyotyping Pregnancy Pregnancy Trimester, First Prenatal Diagnosis / adverse effects, methods* Suction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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