Document Detail

Chorionic villus sampling: cytogenetic experience in preliminary investigations and in 50 diagnostic cases.
MedLine Citation:
PMID:  3460576     Owner:  NLM     Status:  MEDLINE    
The results of preliminary cytogenetic investigations of chorionic villus sampling (CVS) and its diagnostic application in 50 cases are reported. Preliminary investigations included the effect of short delays between biopsy and processing, levels of mitotic activity related to variations in processing, the incidence of tetraploidy, correlation of the karyotype of the chorionic villi with that of the fetus, and the results of banding studies. A protocol was then designed for application to diagnostic CVS. The 50 diagnostic cases included 4 with male karyotypes which were terminated due to a family history of an X-linked disorder, 1 trisomy 21, 1 trisomy 18, the finding of 1 aberrant cell out of 50 in an otherwise normal analysis, a 45, XY, t (13;21) karyotype, 2 fragile X negative karyotypes and in one case the presence of mosaicism was detected in chorionic villi and subsequently not confirmed at amniocentesis. The karyotype on the chorionic villi was 46XY/47XY +3.
L A Stewart; S G Purvis-Smith; D M Wass; M J Bennett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  26     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-08-15     Completed Date:  1986-08-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
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MeSH Terms
Chorionic Villi / ultrastructure*
Chromosome Aberrations / diagnosis
Chromosome Disorders
Mitotic Index
Specimen Handling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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