| Chorionic peptidase inactivates GnRH as a post-proline peptidase. | |
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MedLine Citation:
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PMID: 1502138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, we have described a chorionic peptidase (C-ase-1) which inactivates gonadotropin releasing hormone (GnRH), oxytocin, angiotensin II and thyrotropin releasing hormone. Since all these hormones contain a proline residue, we proposed that C-ase-1 may act as a post-proline peptidase. Using HPLC and amino acid analyses, we have defined the products which resulted from enzymatic inactivation of GnRH by C-ase-1. The N-terminal nonapeptide of GnRH was isolated by HPLC and confirmed by amino acid composition analyses. Thus, it was demonstrated that C-ase-1 acts as a post-proline peptidase when inactivating GnRH, yielding the nonapeptide, i.e., des-Gly10-NH2-GnRH, and Gly-NH2. The levels of intrauterine GnRH, angiotensin II, oxytocin and thyrotropin releasing hormone may be affected and integrated by this enzyme. Thus, C-ase-1 may play an important role in the regulation of the paracrine and endocrine function during pregnancy. |
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Authors:
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I S Kang; T M Siler-Khodr |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Placenta Volume: 13 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 1992 Jan-Feb |
Date Detail:
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Created Date: 1992-09-17 Completed Date: 1992-09-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 81-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology, University of Texas Health Science Center, San Antonio 78284. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis Chromatography, High Pressure Liquid Endopeptidases / pharmacology* Gonadotropin-Releasing Hormone / metabolism* Humans Radioimmunoassay |
| Grant Support | |
ID/Acronym/Agency:
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HD 10202/HD/NICHD NIH HHS; HD 21708/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 33515-09-2/Gonadotropin-Releasing Hormone; EC 3.4.-/Endopeptidases; EC 3.4.99.-/chorionic peptidase I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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