Document Detail


Chorion villus sampling and limb deficiency--cause or coincidence?
MedLine Citation:
PMID:  9509548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chorion villus sampling (CVS) is a widely used technique in first trimester prenatal diagnosis. In the early 1990s, two clusters of babies with limb defects following CVS were reported, raising the possibility of a causal association between early CVS and transverse limb deficiency. The evidence for this association is reviewed and shows a diminishing risk for transverse limb deficiency with advancing gestation. The risk of limb deficiency extends through the period of limb morphogenesis and slightly beyond; falling from levels 10-20-fold above background at nine weeks and below, to levels approaching (or only a few-fold above) background at 11 weeks and beyond.
Authors:
H Firth
Related Documents :
1746618 - Quantitative analysis of associations between birth defects and suspected human teratog...
1861938 - Verbal dyspraxia in treated galactosemia.
15578648 - Trisomy 8 mosaicism in a patient with heterotaxia.
1671898 - Maternal age and birth defects: a population study.
7562288 - Randomized, controlled trial of amoxicillin prophylaxis for prevention of catheter-rela...
24382198 - Stillbirth and infant death among generations of pakistani immigrant descent: a populat...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  17     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1313-30     Citation Subset:  IM    
Affiliation:
Cambridge University Department of Medical Genetics, Addenbrooke's Hospital, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chorionic Villi Sampling / adverse effects*
Extremities / embryology
Female
Gestational Age
Humans
Limb Deformities, Congenital / epidemiology,  etiology*
Pregnancy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rapid detection of aneuploidies by microsatellite and the quantitative fluorescent polymerase chain ...
Next Document:  FIFRA-88, GLP, and QA: pesticide registration.