| Chorion villus sampling and limb deficiency--cause or coincidence? | |
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MedLine Citation:
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PMID: 9509548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chorion villus sampling (CVS) is a widely used technique in first trimester prenatal diagnosis. In the early 1990s, two clusters of babies with limb defects following CVS were reported, raising the possibility of a causal association between early CVS and transverse limb deficiency. The evidence for this association is reviewed and shows a diminishing risk for transverse limb deficiency with advancing gestation. The risk of limb deficiency extends through the period of limb morphogenesis and slightly beyond; falling from levels 10-20-fold above background at nine weeks and below, to levels approaching (or only a few-fold above) background at 11 weeks and beyond. |
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Authors:
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H Firth |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Prenatal diagnosis Volume: 17 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-04-09 Completed Date: 1998-04-09 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1313-30 Citation Subset: IM |
Affiliation:
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Cambridge University Department of Medical Genetics, Addenbrooke's Hospital, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Villi Sampling
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adverse effects* Extremities / embryology Female Gestational Age Humans Limb Deformities, Congenital / epidemiology, etiology* Pregnancy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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