Document Detail

Chorion villus sampling and limb deficiency--cause or coincidence?
MedLine Citation:
PMID:  9509548     Owner:  NLM     Status:  MEDLINE    
Chorion villus sampling (CVS) is a widely used technique in first trimester prenatal diagnosis. In the early 1990s, two clusters of babies with limb defects following CVS were reported, raising the possibility of a causal association between early CVS and transverse limb deficiency. The evidence for this association is reviewed and shows a diminishing risk for transverse limb deficiency with advancing gestation. The risk of limb deficiency extends through the period of limb morphogenesis and slightly beyond; falling from levels 10-20-fold above background at nine weeks and below, to levels approaching (or only a few-fold above) background at 11 weeks and beyond.
H Firth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  17     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1313-30     Citation Subset:  IM    
Cambridge University Department of Medical Genetics, Addenbrooke's Hospital, U.K.
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MeSH Terms
Chorionic Villi Sampling / adverse effects*
Extremities / embryology
Gestational Age
Limb Deformities, Congenital / epidemiology,  etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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