Document Detail

Chorion nodosum: a placental feature of the severe early amnion rupture sequence.
MedLine Citation:
PMID:  16953683     Owner:  NLM     Status:  MEDLINE    
A lesion of placental membranes and/or chorionic disc mesenchyme found in 4 of 13 cases of the limb-body wall complex (LBWC) and in 1 case of term extraamniotic pregnancy, named chorion nodosum (ChN), is described. All five ChN cases were associated with amniotic bands. Although grossly inapparent and histologically superficially similar to amnion nodosum, ChN is a distinct flat lesion located in the chorion denuded of amnion, occurring in different clinical settings, and most probably having a different pathogenesis, because it has bimodal gestational age distribution and occurs earlier in pregnancy when associated with LBWC, and only in the LBWC cases associated with amniotic bands. Therefore, not only oligohydramnios but also other factors involved in etiopathogenesis of LBWC are most probably operative in ChN, such as early vascular disruption, direct contact of the chorion denuded of amnion with fetal body, or a metabolic defect of fetal epidermis and amnionic epithelium. Prolonged severe oligohydramnios most probably plays main role in the pathogenesis of ChN in term extraamniotic pregnancy.
Jerzy Stanek; Adebowale Adeniran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  9     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-60     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, OH 45267-0529, USA.
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MeSH Terms
Abnormalities, Multiple*
Amnion / pathology
Chorion / pathology*
Fetal Membranes, Premature Rupture / pathology*
Oligohydramnios / pathology
Placenta Diseases / pathology*

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