Document Detail

Chorioamnionitis and neonatal encephalopathy in term infants with fetal acidemia: histopathologic correlations.
MedLine Citation:
PMID:  16139729     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine whether the presence or severity of histologic abnormalities of infection/inflammation such as chorioamnionitis, vasculitis, or funisitis confers an additional risk for neonatal encephalopathy in term infants delivered in the presence of severe fetal acidosis. The medical records as well as placental pathology of term infants (n = 51) born with a cord umbilical arterial pH <7.00 were reviewed. Abnormal outcome was predefined as Sarnat stage 2 or 3 neonatal encephalopathy in the first week of life or neonatal death as a consequence of severe brain injury. Consistent with prior data, the presence of severe fetal acidemia, a low 5-minute Apgar score, and need for cardiopulmonary resuscitation were significantly associated with neonatal encephalopathy. However, the presence of histologic chorioamnionitis had a poor predictive value and did not confer additional risk for the subsequent development of neonatal encephalopathy.
Lina Shalak; Sarah Johnson-Welch; Jeffrey M Perlman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  33     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-12-13     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-5     Citation Subset:  IM    
Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, Texas, USA.
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MeSH Terms
Acidosis / complications*,  congenital*
Brain Diseases / etiology*
Chorioamnionitis / pathology*,  prevention & control*
Cohort Studies
Infant, Newborn
Retrospective Studies
Risk Assessment
Severity of Illness Index
Term Birth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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