Document Detail

Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes.
MedLine Citation:
PMID:  15846196     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare morbidities of neonates born to women who developed chorioamnionitis after premature preterm rupture of membranes versus those who did not. STUDY DESIGN: We reviewed outcomes in singleton pregnancies with confirmed premature preterm rupture of membranes at 24 weeks or beyond that resulted in delivery less than 37 weeks. Management of premature preterm rupture of membranes included the use of antibiotics, betamethasone if less than 32 weeks, and expectant management with induction at 34 weeks or greater. Composite neonatal major and minor morbidity rates were compared between pregnancies complicated by chorioamnionitis and those that were not. RESULTS: From August 1998 to August 2000, 430 cases of premature preterm rupture of membranes were identified among 6003 deliveries (7.2%). Thirteen percent of women (56/430) with premature preterm rupture of membranes developed chorioamnionitis. The incidence of chorioamnionitis increased significantly with decreasing gestational age. The composite neonatal major morbidity rate was significantly higher in neonates whose mothers developed chorioamnionitis (55%) versus those who did not (18%, P < .0001). In a multiple logistic regression model, chorioamnionitis ( P < .0001), infant gender ( P = .007), latency ( P = .03), and gestational age at delivery ( P < .0001) were significantly associated with composite neonatal morbidity. CONCLUSION: Neonatal morbidities are significantly higher among pregnancies with premature preterm rupture of membranes complicated by chorioamnionitis when compared with pregnancies that were not.
Patrick S Ramsey; Joelle M Lieman; Cynthia G Brumfield; Waldemar Carlo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  192     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-05-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1162-6     Citation Subset:  AIM; IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics/Gynecology, 458 Old Hillman Building, 619 19th St South, Birmingham, AL, USA.
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MeSH Terms
Apgar Score
Case-Control Studies
Chorioamnionitis / diagnosis,  epidemiology*
Fetal Membranes, Premature Rupture / diagnosis,  epidemiology*
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Newborn, Diseases / diagnosis,  epidemiology*
Logistic Models
Multivariate Analysis
Obstetric Labor, Premature*
Pregnancy Outcome*
Reference Values
Retrospective Studies
Risk Assessment
Severity of Illness Index
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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