Document Detail


Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies.
MedLine Citation:
PMID:  14711859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life. DESIGN: Prospective observational study. SETTING: Regional neonatal intensive care unit. PATIENTS: Thirty five ventilated preterm babies < 33 weeks gestation, seven of whom were born after chorioamnionitis, which was diagnosed histologically as the presence of inflammatory cells in the chorioamnionic plate. METHODS: MMP-8 was measured by enzyme linked immunosorbent assay (ELISA) in 90 serial BAL samples taken during the first six postnatal days. The median MMP-8 concentration for each baby was calculated. RESULTS: Median MMP-8 concentrations were higher in the chorioamnionitis group than in those without (43 v 5 ng/ml). Partial or complete courses of antenatal corticosteroids had no effect on MMP-8 concentrations. CONCLUSIONS: Higher concentrations of MMP-8 are found in BAL fluid from preterm babies from pregnancies complicated by chorioamnionitis. This type I collagenase may contribute to the lung injury that occurs in some babies with respiratory distress syndrome.
Authors:
A E Curley; D G Sweet; K J MacMahon; C M O'Connor; H L Halliday
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  89     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-08     Completed Date:  2004-02-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F61-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Child Health, Queen's University Belfast, and the Regional Neonatal Unit, Royal Maternity Hospital, Belfast, Northern Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / adverse effects*
Birth Weight / physiology
Bronchoalveolar Lavage Fluid*
Chorioamnionitis / complications*
Enzyme-Linked Immunosorbent Assay / methods
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature / metabolism*
Male
Maternal-Fetal Exchange / physiology
Matrix Metalloproteinase 8 / analysis*
Pregnancy
Prenatal Care / methods
Prospective Studies
Risk Factors
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; EC 3.4.24.34/Matrix Metalloproteinase 8
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