| Chorea and developmental regression associated with human herpes virus-6 encephalitis. | |
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MedLine Citation:
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PMID: 23419479 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report a 14-month old child with multiple episodes of febrile status epilepticus, followed by chorea and developmental regression, caused by human herpes virus-6 encephalitis. Chorea has been described as a complication of relapsing herpes simplex virus I infection, but not as a manifestation of human herpes virus-6 infection. It is uncertain whether the chorea was an autoimmune phenomenon or a direct effect of the virus. The child was treated with levetiracetam, intravenous immunoglobulin, and foscarnet. The seizures and chorea resolved with treatment, but developmental regression, with loss of language skills, persisted 6 months after the illness. This child illustrates a new clinical presentation of human herpes virus-6 encephalitis, adds to the spectrum of disorders caused by this virus, and strengthens the case for routine identification of specific viral agents in all cases of childhood viral infections with central nervous system symptoms to determine optimal treatment and prognosis. |
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Authors:
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Anoop S Pulickal; Simi Ramachandran; Philippe Rizek; Pramod Narula; Romaine Schubert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 48 ISSN: 1873-5150 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 249-51 Citation Subset: IM |
Copyright Information:
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Copyright © 2013 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Neonatology, Department of Pediatrics, Brown University, Women & Infants' Hospital, Providence, Rhode Island. Electronic address: apulickal@wihri.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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