Document Detail


Chordoma cutis: a report of nineteen patients with cutaneous involvement of chordoma.
MedLine Citation:
PMID:  7686189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chordoma, an uncommon tumor originating from remnants of the notochord, with cutaneous involvement has rarely been reported. OBJECTIVE: Our purpose was to document clinical manifestations, histopathologic features, immunohistochemical findings, treatment, and course of chordoma with cutaneous involvement. METHODS: Pathologically proven cases of chordoma were reviewed retrospectively for cutaneous involvement. Detailed clinical data and histopathologic changes were studied. Skin biopsy specimens were stained for immunohistochemical phenotyping. RESULTS: Of 207 cases of chordoma, 19 had skin involvement: as local recurrences or metastasis in 12, as direct extension of primary tumor in 6, and as a result of distant metastasis from sacrococcygeal chordoma in 1. Local recurrences were frequent, but distant metastasis to various organs, including skin, occurred. CONCLUSION: We propose the term chordoma cutis to describe this condition. In seven patients, cutaneous lesions were detected when the diagnosis of primary chordoma was made.
Authors:
W P Su; J B Louback; E J Gagne; B W Scheithauer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  29     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-07-23     Completed Date:  1993-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cause of Death
Cell Nucleus / ultrastructure
Chordoma / pathology*
Female
Follow-Up Studies
Humans
Immunohistochemistry
Keratins / analysis
Male
Middle Aged
S100 Proteins / analysis
Sacrococcygeal Region
Skin Neoplasms / pathology*
Survival Rate
Vacuoles / ultrastructure
Vimentin / analysis
Chemical
Reg. No./Substance:
0/S100 Proteins; 0/Vimentin; 68238-35-7/Keratins

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