Document Detail


Chorda tympani nerve modulates the rat's avoidance of calcium chloride.
MedLine Citation:
PMID:  22230254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calcium intake depends on orosensory factors, implying the presence of a mechanism for calcium detection in the mouth. To better understand how information about oral calcium is conveyed to the brain, we examined the effects of chorda tympani nerve transection on calcium chloride (CaCl(2)) taste preferences and thresholds in male Wistar rats. The rats were given bilateral transections of the chorda tympani nerve (CTX) or control surgery. After recovery, they received 48-h two-bottle tests with an ascending concentration series of CaCl(2). Whereas control rats avoided CaCl(2) at concentrations of 0.1mM and higher, rats with CTX were indifferent to CaCl(2) concentrations up to 10mM. Rats with CTX had significantly higher preference scores for 0.316 and 3.16 mM CaCl(2) than did control rats. The results imply that the chorda tympani nerve is required for the normal avoidance of CaCl(2) solution.
Authors:
Glen J Golden; Anna Voznesenskaya; Michael G Tordoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-30
Journal Detail:
Title:  Physiology & behavior     Volume:  105     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-08-15     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1214-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Afferent Pathways / drug effects,  physiology
Animals
Association Learning / drug effects,  physiology
Avoidance Learning / drug effects,  physiology*
Calcium Chloride* / administration & dosage
Chorda Tympani Nerve / injuries,  physiology*
Cranial Nerve Injuries / physiopathology*
Dose-Response Relationship, Drug
Male
Rats
Rats, Wistar
Taste / drug effects,  physiology
Taste Threshold / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
DC-10149/DC/NIDCD NIH HHS; P30 DC011735/DC/NIDCD NIH HHS; R01 DC010149/DC/NIDCD NIH HHS; R01 DC010149-03/DC/NIDCD NIH HHS; R01 DK046791/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
M4I0D6VV5M/Calcium Chloride
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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