Document Detail

Chorangiosis: the potential role of smoking and air pollution.
MedLine Citation:
PMID:  18635319     Owner:  NLM     Status:  MEDLINE    
Chorangiosis is considered to be strongly associated with various fetal, maternal, and placental disorders, including pre-eclampsia, diabetes, hypertension, and major congenital anomalies, and has been found to correlate with increased fetal morbidity and mortality. In this study, we investigated the pathologic effects of maternal smoking and air pollution on the pathogenesis of chorangiosis. We investigated 92 placentas macroscopically and microscopically over a 3-month period (March 2006-May 2006) at Denizli State Hospital to identify the frequency of chorangiosis and the potential role of maternal smoking and air pollution. Placental changes were examined by light microscopy after hematoxylin and eosin (H&E) staining and immunohistochemical evaluation of CD 34 and CD 68; muscle-specific actin was used to confirm the diagnosis. Among the 92 mothers included in the study, 33 were smokers (group I), 31 were thought to have been exposed to air pollution (group II), and 28 were living in rural areas free of air pollution and maternal smoking (group III). Chorangiosis was found in 14% (13/92) of all placentas: 7 (53.8%) cases were assigned to group I, 5 (38.5%) to group II, and 1 (7.7%) to group III. Vascular changes were found mainly in the smoking and air pollution groups. There appeared to be no correlation of these vascular changes with placental weight, parity, gestational age, major congenital anomalies, and maternal factors, including diabetes and pre-eclampsia. We presume that smoking and air pollution may contribute to the development of chorangiosis. We suggest that chorangiosis may be an adaptive response to maternal hypoxia, and studies addressing the role of smoking and air pollution in chorangiosis may provide new insights into the pathogenesis of this condition.
Metin Akbulut; Hulya Cetin Sorkun; Ferda Bir; Ayhan Eralp; Ender Duzcan
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Publication Detail:
Type:  Journal Article     Date:  2008-07-16
Journal Detail:
Title:  Pathology, research and practice     Volume:  205     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Department of Pathology, Pamukkale University School of Medicine, Denizli 20030, Turkey.
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MeSH Terms
Air Pollution / adverse effects*
Chorionic Villi / blood supply*,  pathology*
Maternal Exposure / adverse effects
Placenta Diseases / etiology*,  pathology
Pregnancy Complications / etiology*,  pathology
Smoking / adverse effects*

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