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Chondrosarcoma: with updates on molecular genetics.
MedLine Citation:
PMID:  21403832     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of CHS. The prognosis of CHS is closely related to histologic grading, however, histologic grading may be subjective with high inter-observer variability. In this paper, we present histologic grading system and clinicopathological and radiological findings of conventional CHS. Subtypes of CHSs, such as dedifferentiated, mesenchymal, and clear cell CHSs are also presented. In addition, we introduce updated cytogenetic and molecular genetic findings to expand our understanding of CHS biology. New markers of cell differentiation, proliferation, and cell signaling might offer important therapeutic and prognostic information in near future.
Authors:
Mi-Jung Kim; Kyung-Ja Cho; Alberto G Ayala; Jae Y Ro
Publication Detail:
Type:  Journal Article     Date:  2011-02-15
Journal Detail:
Title:  Sarcoma     Volume:  2011     ISSN:  1369-1643     ISO Abbreviation:  Sarcoma     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-07-14     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  9709257     Medline TA:  Sarcoma     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  405437     Citation Subset:  -    
Affiliation:
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
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