| Chondrosarcoma: with updates on molecular genetics. | |
| | |
MedLine Citation:
|
PMID: 21403832 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of CHS. The prognosis of CHS is closely related to histologic grading, however, histologic grading may be subjective with high inter-observer variability. In this paper, we present histologic grading system and clinicopathological and radiological findings of conventional CHS. Subtypes of CHSs, such as dedifferentiated, mesenchymal, and clear cell CHSs are also presented. In addition, we introduce updated cytogenetic and molecular genetic findings to expand our understanding of CHS biology. New markers of cell differentiation, proliferation, and cell signaling might offer important therapeutic and prognostic information in near future. |
| | |
Authors:
|
Mi-Jung Kim; Kyung-Ja Cho; Alberto G Ayala; Jae Y Ro |
Publication Detail:
|
Type: Journal Article Date: 2011-02-15 |
Journal Detail:
|
Title: Sarcoma Volume: 2011 ISSN: 1369-1643 ISO Abbreviation: Sarcoma Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-03-15 Completed Date: 2011-07-14 Revised Date: 2011-07-26 |
Medline Journal Info:
|
Nlm Unique ID: 9709257 Medline TA: Sarcoma Country: Egypt |
Other Details:
|
Languages: eng Pagination: 405437 Citation Subset: - |
Affiliation:
|
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Animal models of cardiovascular diseases.
Next Document: Benefits of exercise in rheumatoid arthritis.