Document Detail


Chondrosarcoma of the larynx: the role of radiotherapy revisited--a case report and review of the literature.
MedLine Citation:
PMID:  9428486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Experience in the treatment of laryngeal chondrosarcoma is based on about 250 cases reported to date. The standard therapy is conservative surgery. Radiotherapy has universally been regarded as ineffective in the treatment of this disease. METHODS: A patient with a laryngeal chondrosarcoma was observed for 11 years after radical radiotherapy. The literature on laryngeal chondrosarcoma was critically reviewed, with emphasis placed on radiotherapy. RESULTS: The review of the literature revealed that experience with radiotherapy of laryngeal chondrosarcoma has been lacking, with fewer than 10 cases with short follow-up documented up to now. Meanwhile, increasing evidence of the efficacy of radiotherapy in the treatment of skeletal chondrosarcoma has emerged. The authors report the first case of chondrosarcoma of the larynx in which radical radiotherapy resulted in a long term remission of more than 10 years. CONCLUSIONS: Radiotherapy should be considered when radical surgery is not feasible without severe mutilation. It should also be considered for the treatment of residual disease. Laryngectomy should be restricted to salvage treatment when radiotherapy fails. In this study, radiotherapy appeared to be an effective modality in the treatment of low grade laryngeal chondrosarcoma, and these results contrast with the current widespread disapproval of this treatment.
Authors:
S Gripp; H Pape; G Schmitt
Related Documents :
19927966 - Influence of bedrest or ambulation in the clinical treatment of acute deep vein thrombo...
10197856 - Venous malformation of the glans penis: efficacy of treatment with neodymium:yttruim-al...
19093116 - Dermatomyositis, complicated with pneumomediastinum, successfully treated with cyclospo...
20683936 - Isolated laryngeal myokymia: diagnosis and treatment.
22606606 - Conservative management of a congenital seminal vesicle cyst associated with ipsilatera...
12559306 - Management of priapism in the newborn.
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer     Volume:  82     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-02     Completed Date:  1998-02-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  108-15     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiation Oncology, Heinrich-Heine-University Duesseldorf, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Bone Neoplasms / radiotherapy
Chondrosarcoma / radiotherapy*,  surgery
Feasibility Studies
Follow-Up Studies
Humans
Laryngeal Neoplasms / radiotherapy*,  surgery
Laryngectomy
Longitudinal Studies
Male
Neoplasm, Residual / radiotherapy
Remission Induction
Salvage Therapy
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Squamous cell carcinoma of the maxillary sinus treated with radiation therapy and conservative surge...
Next Document:  Single agent versus combination chemotherapy in patients with advanced nonsmall cell lung carcinoma:...