Document Detail

Chondrosarcoma of the larynx: the role of radiotherapy revisited--a case report and review of the literature.
MedLine Citation:
PMID:  9428486     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Experience in the treatment of laryngeal chondrosarcoma is based on about 250 cases reported to date. The standard therapy is conservative surgery. Radiotherapy has universally been regarded as ineffective in the treatment of this disease. METHODS: A patient with a laryngeal chondrosarcoma was observed for 11 years after radical radiotherapy. The literature on laryngeal chondrosarcoma was critically reviewed, with emphasis placed on radiotherapy. RESULTS: The review of the literature revealed that experience with radiotherapy of laryngeal chondrosarcoma has been lacking, with fewer than 10 cases with short follow-up documented up to now. Meanwhile, increasing evidence of the efficacy of radiotherapy in the treatment of skeletal chondrosarcoma has emerged. The authors report the first case of chondrosarcoma of the larynx in which radical radiotherapy resulted in a long term remission of more than 10 years. CONCLUSIONS: Radiotherapy should be considered when radical surgery is not feasible without severe mutilation. It should also be considered for the treatment of residual disease. Laryngectomy should be restricted to salvage treatment when radiotherapy fails. In this study, radiotherapy appeared to be an effective modality in the treatment of low grade laryngeal chondrosarcoma, and these results contrast with the current widespread disapproval of this treatment.
S Gripp; H Pape; G Schmitt
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer     Volume:  82     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-02     Completed Date:  1998-02-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  108-15     Citation Subset:  AIM; IM    
Department of Radiation Oncology, Heinrich-Heine-University Duesseldorf, Germany.
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MeSH Terms
Bone Neoplasms / radiotherapy
Chondrosarcoma / radiotherapy*,  surgery
Feasibility Studies
Follow-Up Studies
Laryngeal Neoplasms / radiotherapy*,  surgery
Longitudinal Studies
Neoplasm, Residual / radiotherapy
Remission Induction
Salvage Therapy
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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