| Chondroitin sulfate and kallikrein in saliva: markers for glossodynia. | |
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MedLine Citation:
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PMID: 18486918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glossodynia or burning mouth syndrome is a multifunctional disorder. The oral mucosa is apparently normal but patients report burning and dried mouth and painful tongue and lips. The present study reports biochemical and physiological markers in saliva of patients presenting glossodynia compared to normal subjects. Saliva-buffering capacity and contents of protein and hyaluronic (HA) acid were similar in both groups. In contrast, chondroitin sulfate (CS) concentration was decreased in the saliva of patients with glossodynia when compared to control group (p=0.0036). On the other hand glandular kallikrein showed increased activity in the saliva of patients compared to normal subjects (p<0.0001). The data suggest involvement of the kinin system, possibly related to the low levels of CS. Depression could explain the low level of serotonin in patient serum (p=0.0478). |
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Authors:
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L M Loeb; M G Naffah-Mazzacoratti; M A Porcionatto; J R M Martins; M Kouyoumdjian; L M Weckx; H B Nader |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-28 |
Journal Detail:
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Title: International immunopharmacology Volume: 8 ISSN: 1567-5769 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-05-19 Completed Date: 2008-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1056-8 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, UNIFESP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Chondroitin Sulfates / analysis* Glossalgia / diagnosis*, metabolism Humans Kallikreins / analysis* Saliva / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9007-28-7/Chondroitin Sulfates; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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