Document Detail


Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.
MedLine Citation:
PMID:  18800802     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammatory factors are known to play a key role in promoting tumorigenesis; therefore, it is a promising strategy to inhibit the inflammation for cancer prevention. The current study was performed to investigate the potential effects of chondroitin sulfate (CS) extracted from ascidian tunic on the expression of inflammatory factors induced by treatment with 12- O-tetradecanoylphorbol-13-acetate (TPA) and to elucidate the underlying molecular mechanism of CS action in mouse skin inflammation. TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin. These studies suggest that CS from ascidian tunic may be developed as an effective natural anti-inflammatory agent.
Authors:
Cheng-Xiong Xu; Hua Jin; Youn-Sun Chung; Ji-Young Shin; Kee-Ho Lee; George R Beck; Grace N Palmos; Byeong-Dae Choi; Myung-Haing Cho
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-09-19
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-16     Completed Date:  2008-12-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9667-75     Citation Subset:  IM    
Affiliation:
Laboratory of Toxicology, Seoul National University, Seoul 151-742, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / pharmacology
Cell Extracts / pharmacology
Chondroitin Sulfates / chemistry,  isolation & purification,  pharmacology*
Cyclooxygenase 2 / genetics*,  metabolism
Down-Regulation* / drug effects
Female
Gene Expression / drug effects
Humans
Inflammation / drug therapy*,  genetics,  metabolism
Mice
Mice, Inbred ICR
NF-kappa B / genetics*,  metabolism
Phorbol Esters / pharmacology*
Phosphorylation / drug effects
Random Allocation
Signal Transduction
Skin / drug effects*,  metabolism
Urochordata / chemistry,  metabolism
Vascular Cell Adhesion Molecule-1 / genetics*,  metabolism
Grant Support
ID/Acronym/Agency:
CA84573/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Cell Extracts; 0/NF-kappa B; 0/Phorbol Esters; 0/Vascular Cell Adhesion Molecule-1; 9007-28-7/Chondroitin Sulfates; EC 1.14.99.-/Ptgs2 protein, mouse; EC 1.14.99.1/Cyclooxygenase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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