Document Detail

Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy.
MedLine Citation:
PMID:  12210573     Owner:  NLM     Status:  MEDLINE    
We describe a 2-year-old boy with chondrodysplasia punctata (CDP). The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy. There has been previous evidence for a connection between phenytoin exposure during pregnancy and chondrodysplasia punctata. The boy had clinical and some radiological characteristic features of CDP, of the tibia-metacarpal type. We know of no other report on a child exposed to phenytoin during pregnancy who developed CDP of this type.
U Wester; G Brandberg; M Larsson; T Lönnerholm; G Annerén
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  22     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2003-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  663-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Unit of Paediatrics, Department of Women and Child Heath, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Anticonvulsants / adverse effects*
Carbamazepine / adverse effects*
Child, Preschool
Chondrodysplasia Punctata / diagnosis*,  etiology*
Craniofacial Abnormalities / etiology
Epilepsy / drug therapy
Fetal Growth Retardation / ultrasonography
Maternal-Fetal Exchange*
Metacarpus / radiography
Phenytoin / adverse effects*
Pregnancy Complications / drug therapy
Tibia / radiography
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine; 57-41-0/Phenytoin

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