Document Detail

Chondrocyte nuclear response to osmotic loading.
MedLine Citation:
PMID:  17947048     Owner:  NLM     Status:  MEDLINE    
Cartilage compression results in changes in the shape, volume as well as hydrostatic and osmotic pressure of chondrocytes in situ. For example, changes in the cellular osmotic environment have been shown to modulate chondrocyte biosynthesis and gene expression, however, the mechanosensing mechanisms mediating these responses are relatively unknown. Nuclear shape and size changes resulting from cell deformation have been suggested to alter cell functions, and as such we recently performed a study that reported that chondrocytes and their nuclei respond to osmotic loading with alterations in their size. In the current study, we focus on the potential role of the actin cytoskeleton in mediating the transmission of osmotic loading-induced cell size changes to the nucleus.
Elizabeth S Oswald; Pen-hsiu G Chao; J Chloe Bulinski; Gerard A Ateshian; Clark T Hung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  1     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2006  
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-03-07     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3659-61     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / drug effects,  physiology*,  ultrastructure
Cell Shape
Chondrocytes / cytology,  physiology*
Cytochalasin D / pharmacology
Hydrostatic Pressure
Models, Biological
Osmotic Pressure
Grant Support
Reg. No./Substance:
22144-77-0/Cytochalasin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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