Document Detail

Chondrichthyans have a bulbus arteriosus at the arterial pole of the heart: morphological and evolutionary implications.
MedLine Citation:
PMID:  18803558     Owner:  NLM     Status:  MEDLINE    
It has been generally assumed that the outflow tract of the chondrichthyan heart consists of the conus arteriosus, characterized by cardiac muscle in its walls. However, classical observations, neglected for many years, indicated that the distal component of the cardiac outflow tract of several elasmobranch species was composed of tissue resembling that of the ventral aorta. The present study was outlined to test the hypothesis that this intrapericardial, non-myocardial component might be homologous to the actinopterygian bulbus arteriosus. The material consisted of Atlantic catshark adults and embryos, which were examined by means of histochemical and immunohistochemical techniques for light and fluorescence microscopy. In this species, the distal component of the outflow tract differs histomorphologically from both the ventral aorta and the conus arteriosus; it is devoid of myocardium, is covered by epicardium and is crossed by the coronary arterial trunks. In the embryonic hearts examined, this distal component showed positive reactivity for 4,5-diaminofluorescein 2-diacetate (DAF-2DA), a fluorescent nitric oxide indicator. These findings, together with other observations in holocephals and several elasmobranch species, confirm that chondrichthyans possess a bulbus arteriosus interposed between the conus arteriosus and the ventral aorta. Therefore, the primitive heart of gnathostomates consists of five intrapericardial components, sinus venosus, atrium, ventricle, conus arteriosus and bulbus arteriosus, indicating that the bulbus arteriosus can no longer be regarded as an actinopterygian apomorphy. The DAF-2DA-positive reactivity of the chondrichthyan embryonic bulbus suggests that this structure is homologous to the base of the great arterial trunks of birds and mammals, which derives from the embryonic secondary heart field.
Ana C Durán; Borja Fernández; Adrian C Grimes; Cristina Rodríguez; Josep M Arqué; Valentín Sans-Coma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of anatomy     Volume:  213     ISSN:  1469-7580     ISO Abbreviation:  J. Anat.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-02-20     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  England    
Other Details:
Languages:  eng     Pagination:  597-606     Citation Subset:  IM    
Departamento de Biología Animal, Facultad de Ciencias, Universidad de Málaga, Spain.
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MeSH Terms
Arteries / anatomy & histology,  embryology
Biological Markers / analysis
Heart / anatomy & histology*
Nitric Oxide / analysis
Sharks / anatomy & histology*,  embryology
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide

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