| Cholinesterases, a target of pharmacology and toxicology. | |
| | |
MedLine Citation:
|
PMID: 22286807 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and acetylcholinesterase (AChE), AChE plays the key role in ending cholinergic neurotransmission. Cholinesterase inhibitors are substances, either natural or man-made that interfere with the break-down of ACh and prolong its action. Hence their relevance to toxicology and pharmacology. Methods and Results. The present review summarizes current knowledge of the cholinesterases and their inhibition. Particular attention is paid to the toxicology and pharmacology of cholinesterase-related inhibitors such as nerve agents (e.g. sarin, soman, tabun, VX), pesticides (e.g. paraoxon, parathion, malathion, malaoxon, carbofuran), selected plants and fungal secondary metabolites (e.g. aflatoxins), drugs for Alzheimer's disease (e.g. huperzine, metrifonate, tacrine, donepezil) and Myasthenia gravis (e.g. pyridostigmine) treatment and other compounds (propidium, ethidium, decamethonium). Conclusions. The crucial role of the cholinesterases in neural transmission makes them a primary target of a large number of cholinesterase-inhibiting drugs and toxins. In pharmacology, this has relevance to the treatment of neurodegenerative disorders. |
| | |
Authors:
|
Miroslav Pohanka |
Related Documents
:
|
15929457 - Preventing ischemic stroke: choosing the best strategy. 22781877 - Non-medical use of prescription drugs among mississippi youth: constitutional, psycholo... 22331367 - Tinnitus. 22698937 - Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more ... 8429687 - Effects of carboplatin in combination with other anticancer agents on human leukemia ce... 1441597 - Methylation pharmacogenetics: thiopurine methyltransferase as a model system. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia Volume: 155 ISSN: 1213-8118 ISO Abbreviation: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2012-01-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140142 Medline TA: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Country: Czech Republic |
Other Details:
|
Languages: eng Pagination: 219-29 Citation Subset: IM |
Affiliation:
|
Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove, Czech Republic. miroslav.pohanka@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fatty acids as biocompounds: their role in human metabolism, health and disease - a review. Part 2: ...
Next Document: Genetic syndromes associated with renal cell carcinoma - a review.