| Cholinesterases and the pathology of Alzheimer disease. | |
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MedLine Citation:
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PMID: 8534419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alzheimer disease (AD) is accompanied by a marked loss of acetylcholinesterase (AChE) activity associated with cortical cholinergic axons and cholinoceptive neurons. Simultaneous with this loss, cholinesterase (ChE) activity emerges in AD cortex in the form of AChE and butyrylcholinesterase activity associated with plaques, tangles, and amyloid angiopathy. Our observations have shown that the ChEs associated with the pathological lesions of AD (ADChEs) possess different enzymatic properties and quite possibly are of a different source as compared with the ChEs associated with normal neurons and axons. The ADChEs most likely have noncholinergic functions involved in the pathogenesis of AD. The postulated functions include acting as proteases/peptidases, participating directly in the amyloidogenic processing of the amyloid precursor protein, and causing aberrant growth of neuronal processes. The therapeutic and diagnostic implications of ADChEs are discussed. |
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Authors:
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C Geula; M M Mesulam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Alzheimer disease and associated disorders Volume: 9 Suppl 2 ISSN: 0893-0341 ISO Abbreviation: Alzheimer Dis Assoc Disord Publication Date: 1995 |
Date Detail:
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Created Date: 1996-02-07 Completed Date: 1996-02-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8704771 Medline TA: Alzheimer Dis Assoc Disord Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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metabolism* Alzheimer Disease / enzymology*, pathology* Brain / enzymology Cholinesterases / metabolism* Humans Neurofibrillary Tangles / enzymology |
| Grant Support | |
ID/Acronym/Agency:
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AG10282/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.7/Acetylcholinesterase; EC 3.1.1.8/Cholinesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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