Document Detail

Cholinesterase inhibitors in Alzheimer's disease: efficacy in a non-selected population.
MedLine Citation:
PMID:  15055749     Owner:  NLM     Status:  MEDLINE    
This paper presents preliminary results on the efficacy of acetyl-cholinesterase inhibitors (ChE-I) administered in a population of patients with mild-to-moderate Alzheimer's disease (AD), recruited in the context of an Italian Department of Health supported project (Progetto Cronos). The patients were followed up for a maximum of 21 months. Around 45% of the subjects responded well to the treatment (i.e., stable or improved Mini Mental State) at the end of the 9th month. Thereafter, a global cognitive and functional decline was reported, more marked in basic daily activities. No factors (age, sex, disease duration, family history for AD, cognitive impairment at baseline) emerged as predictors of outcome.
Elena Sinforiani; Lara Maria Banchieri; Chiara Zucchella; Luca Bernasconi; Giuseppe Nappi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Functional neurology     Volume:  18     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    2003 Oct-Dec
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-04-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Alzheimer's Disease Assessment Unit and Laboratory of Neuropsychology, IRCCS C. Mondino Institute of Neurology, Pavia, Italy.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / drug therapy*,  psychology
Cholinesterase Inhibitors / therapeutic use*
Middle Aged
Psychiatric Status Rating Scales
Regression Analysis
Reg. No./Substance:
0/Cholinesterase Inhibitors

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