| Cholinesterase inhibitors in Alzheimer's disease: efficacy in a non-selected population. | |
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MedLine Citation:
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PMID: 15055749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper presents preliminary results on the efficacy of acetyl-cholinesterase inhibitors (ChE-I) administered in a population of patients with mild-to-moderate Alzheimer's disease (AD), recruited in the context of an Italian Department of Health supported project (Progetto Cronos). The patients were followed up for a maximum of 21 months. Around 45% of the subjects responded well to the treatment (i.e., stable or improved Mini Mental State) at the end of the 9th month. Thereafter, a global cognitive and functional decline was reported, more marked in basic daily activities. No factors (age, sex, disease duration, family history for AD, cognitive impairment at baseline) emerged as predictors of outcome. |
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Authors:
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Elena Sinforiani; Lara Maria Banchieri; Chiara Zucchella; Luca Bernasconi; Giuseppe Nappi |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Functional neurology Volume: 18 ISSN: 0393-5264 ISO Abbreviation: Funct. Neurol. Publication Date: 2003 Oct-Dec |
Date Detail:
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Created Date: 2004-04-01 Completed Date: 2004-04-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707746 Medline TA: Funct Neurol Country: Italy |
Other Details:
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Languages: eng Pagination: 233-7 Citation Subset: IM |
Affiliation:
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Alzheimer's Disease Assessment Unit and Laboratory of Neuropsychology, IRCCS C. Mondino Institute of Neurology, Pavia, Italy. elena.sinforiani@mondino.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / drug therapy*, psychology Cholinesterase Inhibitors / therapeutic use* Female Humans Male Middle Aged Psychiatric Status Rating Scales Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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