Document Detail

Cholinergic urticaria: acetylcholine-receptor-dependent immediate-type hypersensitivity reaction to copper.
MedLine Citation:
PMID:  6188007     Owner:  NLM     Status:  MEDLINE    
A patient with cholinergic urticaria syndrome was found to have an unusually large number of muscarinic cholinergic receptors in the urticarial sites. The amplification of these receptors may account for her heightened sensitivity to acetylcholine discharge following exercise, heat, and emotion. The acetylcholine presumably acts directly on the mast-cell membrane to initiate histamine release and thereby punctate urticaria. In addition, an otherwise occult sensitivity to copper was detected with a 48 h contact patch test to the metal followed by an exercise challenge. Under these conditions, the patch test site developed hives after the autonomic stress stimulus of exercise but showed nothing on conventional patch testing before exercise. Such "cholinergic patch testing" is recommended for the demonstration of other examples of antigen enhancement of acetylcholine-mediated reactions.
W B Shelley; E D Shelley; A K Ho
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  843-6     Citation Subset:  AIM; IM    
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MeSH Terms
Acetylcholine / metabolism
Cell Membrane / metabolism
Histamine Release
Hypersensitivity, Immediate / metabolism*
Intrauterine Devices, Copper / adverse effects*
Mast Cells / metabolism
Parasympathetic Nervous System / metabolism
Physical Exertion
Receptors, Cholinergic / metabolism*
Receptors, Muscarinic / metabolism*
Skin / metabolism
Urticaria / etiology*,  metabolism
Reg. No./Substance:
0/Receptors, Cholinergic; 0/Receptors, Muscarinic; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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