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Cholinergic stimulation with pyridostigmine improves autonomic function in infarcted rats.
MedLine Citation:
PMID:  23701019     Owner:  NLM     Status:  Publisher    
We evaluated the effects of short-term pyridostigmine bromide (0.14 mg/ml) treatment started early after myocardial infarction (MI) on the left ventricular (LV) and autonomic function of rats. Male Wistar rats were divided into: control, pyridostigmine, infarcted, infarcted+ pyridostigmine. Pyridostigmine treatment in the drink water began immediately after MI or Sham and continued during 11 days. LV function was evaluated indirectly by echocardiography and directly by LV catheterization. Cardiovascular autonomic control was evaluated by baroreflex sensitivity (BRS), heart rate variability (HRV) and pharmacological blockade. All evaluations began 7 days after pyridostigmine treatment and were finalized 11 days after treatment initiation. Pyridostigmine treatment prevented the impairment of +dP/dT, and reduced MI area in infarcted+pyridostigmine (7±3%) as compared to infarcted (17±4%) rats. Mean blood pressure values were restored in infarcted+pyridostigmine (103±2.7 mmHg) group in comparison with infarcted (94±2.9 mmHg). Pyridostigmine treatment improved BRS evaluated by tachycardic (infarcted+pyridostigmine: 2.5±0.22 vs. infarcted: 1.6±0.20 bpm/mmHg) and bradycardic (infarcted+pyridostigmine: -1.9±0.10 vs. infarcted: -0.4±0.01 bpm/mmHg) responses, as well as reduced low frequency/high frequency ratio of HRV (infarcted+pyridostigmine: 0.24±0.14 vs. infarcted: 0.81±0.11). These improvements are probably associated with the increased vagal tonus and the sympathetic tonus reduction in infarcted+pyridostigmine rats as compared with infarcted. Our data suggest that the short-term pyridostigmine treatment started early after MI can improve BRS, HRV, parasympathetic and sympathetic tonus in experimental rats. These data may have potential clinical implications since autonomic markers have prognostic significance after MI. This article is protected by copyright. All rights reserved.
Rn de La Fuente; B Rodrigues; Ic Moraes-Silva; LE Souza; R Sirvente; C Mostarda; K De Angelis; Pp Soares; S Lacchini; Mc Irigoyen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-23
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Heart Institute (InCor), Medical School of University of Sao Paulo, Sao Paulo, Brazil.
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