| Cholinergic signal activated renin angiotensin system associated with cardiovascular changes in the ovine fetus. | |
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MedLine Citation:
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PMID: 19921993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Cholinergic regulation is important in the control of cardiovascular and endocrine responses. The mechanisms behind cardiovascular responses induced by cholinergic activation are explored by studying hormonal systems, including renin-angiotensin and vasopressin (VP). RESULTS: In chronically prepared fetal sheep, intravenous infusion of the cholinergic agonist carbachol increased fetal systolic, diastolic, and mean arterial pressure accompanied with bradycardia at near-term. Although intravenous administration of carbachol had no effect on plasma VP concentrations, this agonist increased angiotensin I and angiotensin II levels in fetal plasma. Fetal blood values, including sodium, osmolality, nitric oxide, hemoglobin, and hematocrit were unchanged by intravenous carbachol. CONCLUSION: Cholinergic activation by carbachol controls fetal blood pressure and heart rate in utero. An over-activated fetal renin-angiotensin-system (RAS) is associated with changes in vascular pressure following intravenous administration of carbachol, indicating that the cholinergic stimulation-mediated hormonal mechanism in the fetus might play a critical role in the regulation of cardiovascular homeostasis. |
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Authors:
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Chunsong Geng; Caiping Mao; Lei Wu; Yu Cheng; Rulu Liu; Bingxin Chen; Ling Chen; Lubo Zhang; Zhice Xu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 38 ISSN: 1619-3997 ISO Abbreviation: J Perinat Med Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-05 Completed Date: 2010-04-02 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 71-6 Citation Subset: IM |
Affiliation:
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Perinatal Origin Diseases Research Institute, First Affiliated Hospital of Soochow University, Suzhou, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbachol / diagnostic use Cholinergic Agonists / diagnostic use Female Fetal Blood / metabolism Fetal Heart / physiology* Pregnancy Pregnancy, Animal / metabolism* Receptors, Cholinergic / metabolism* Renin-Angiotensin System* Sheep Vasopressins / blood* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL083966-05/HL/NHLBI NIH HHS; R01 HL089012-03/HL/NHLBI NIH HHS; R01 HL089012-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Agonists; 0/Receptors, Cholinergic; 11000-17-2/Vasopressins; 51-83-2/Carbachol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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