Document Detail

Cholinergic responsiveness of the individual airway after allergen instillation in sensitised pigs.
MedLine Citation:
PMID:  15123229     Owner:  NLM     Status:  MEDLINE    
Allergen exposure of sensitised lungs produces bronchial hyperresponsiveness in vivo associated with airway inflammation and remodelling. It is unclear if hyperresponsiveness is also present in airways in vitro under similar conditions of drug provocation as carried out in vivo, and at different times after allergen-challenge. This study records responsiveness of individual airway segments to acetylcholine (ACh) in sensitised bronchi after instillation of allergen (ovalbumin, OA). Airway histology and sensitivity and maximum effects to ACh were recorded 1, 24 and 72 h and 1 week after OA. OA-instilled airways exhibited eosinophilia and epithelial proliferation. Physiological recordings showed no change in maximum contractions of airway segments to acetylcholine placed in the airway lumen except at 24 h where they were reduced. In contrast maximum contractions to ACh to the airway adventitia were reduced at all times except 1 week, with the greatest change occurring at 24 h. There were no changes in airway sensitivity to either route of ACh in OA-instilled airways but the difference in sensitivity to adventitial and lumenal ACh was reduced. Results show that allergen does not produce hyperresponsiveness at the airway wall but it may alter an interaction between airway smooth muscle and other structural components of the airway.
H W Mitchell; D J Turner; P B Noble
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  17     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-05     Completed Date:  2004-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, and Western Australian Institute for Medical Research, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia.
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MeSH Terms
Acetylcholine / pharmacology*
Allergens / administration & dosage,  immunology
Bronchi / drug effects*,  pathology,  physiopathology
Bronchial Hyperreactivity / immunology,  pathology,  physiopathology*
Cell Division
Eosinophils / pathology
Instillation, Drug
Muscle, Smooth / pathology
Ovalbumin / administration & dosage,  immunology
Respiratory Mucosa / pathology
Reg. No./Substance:
0/Allergens; 51-84-3/Acetylcholine; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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