| Cholinergic responsiveness of the individual airway after allergen instillation in sensitised pigs. | |
| | |
MedLine Citation:
|
PMID: 15123229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Allergen exposure of sensitised lungs produces bronchial hyperresponsiveness in vivo associated with airway inflammation and remodelling. It is unclear if hyperresponsiveness is also present in airways in vitro under similar conditions of drug provocation as carried out in vivo, and at different times after allergen-challenge. This study records responsiveness of individual airway segments to acetylcholine (ACh) in sensitised bronchi after instillation of allergen (ovalbumin, OA). Airway histology and sensitivity and maximum effects to ACh were recorded 1, 24 and 72 h and 1 week after OA. OA-instilled airways exhibited eosinophilia and epithelial proliferation. Physiological recordings showed no change in maximum contractions of airway segments to acetylcholine placed in the airway lumen except at 24 h where they were reduced. In contrast maximum contractions to ACh to the airway adventitia were reduced at all times except 1 week, with the greatest change occurring at 24 h. There were no changes in airway sensitivity to either route of ACh in OA-instilled airways but the difference in sensitivity to adventitial and lumenal ACh was reduced. Results show that allergen does not produce hyperresponsiveness at the airway wall but it may alter an interaction between airway smooth muscle and other structural components of the airway. |
| | |
Authors:
|
H W Mitchell; D J Turner; P B Noble |
Related Documents
:
|
7065539 - Pattern and time course of ventilation-perfusion inequality in exercise-induced asthma. 10709939 - Effect and absorption of histamine in sheep rumen: significance of acidotic epithelial ... 2764369 - Localization of the site of the bronchoconstrictor effects of leukotriene c4 compared w... 3595219 - Pulmonary function abnormalities in intentional spray paint inhalation. 10712309 - Endogenous airway acidification. implications for asthma pathophysiology. 11860169 - Blood eosinophil counts for the prediction of the severity of exercise-induced bronchos... 7745399 - Inter-relation between "classic" motor neuron disease and frontotemporal dementia: neur... 22522589 - Emerging concept: 'central benefit model' of exercise in falls prevention. 8321109 - Chronic endurance exercise training: a condition of inadequate blood pressure regulatio... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pulmonary pharmacology & therapeutics Volume: 17 ISSN: 1094-5539 ISO Abbreviation: Pulm Pharmacol Ther Publication Date: 2004 |
Date Detail:
|
Created Date: 2004-05-05 Completed Date: 2004-06-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9715279 Medline TA: Pulm Pharmacol Ther Country: England |
Other Details:
|
Languages: eng Pagination: 81-8 Citation Subset: IM |
Affiliation:
|
Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, and Western Australian Institute for Medical Research, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia. mitchell@cyllene.uwa.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
pharmacology* Allergens / administration & dosage, immunology Animals Bronchi / drug effects*, pathology, physiopathology Bronchial Hyperreactivity / immunology, pathology, physiopathology* Cell Division Eosinophils / pathology Female Instillation, Drug Muscle, Smooth / pathology Ovalbumin / administration & dosage, immunology Respiratory Mucosa / pathology Swine |
| Chemical | |
Reg. No./Substance:
|
0/Allergens; 51-84-3/Acetylcholine; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adre...
Next Document: Budesonide/formoterol in a single inhaler rapidly relieves methacholine-induced moderate-to-severe b...