Document Detail


Cholinergic regulation of airway inflammation and remodelling.
MedLine Citation:
PMID:  22291719     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Acetylcholine is the predominant parasympathetic neurotransmitter in the airways that regulates bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine regulates additional functions in the airways, including inflammation and remodelling during inflammatory airway diseases. Moreover, it has become apparent that acetylcholine is synthesized by nonneuronal cells and tissues, including inflammatory cells and structural cells. In this paper, we will discuss the regulatory role of acetylcholine in inflammation and remodelling in which we will focus on the role of the airway smooth muscle cell as a target cell for acetylcholine that modulates inflammation and remodelling during respiratory diseases such as asthma and COPD.
Authors:
Saeed Kolahian; Reinoud Gosens
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Publication Detail:
Type:  Journal Article     Date:  2012-01-16
Journal Detail:
Title:  Journal of allergy     Volume:  2012     ISSN:  1687-9791     ISO Abbreviation:  J Allergy (Cairo)     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101535174     Medline TA:  J Allergy (Cairo)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  681258     Citation Subset:  -    
Affiliation:
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Iran.
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