| Cholinergic and pancreatic actions of purified porcine and synthetic vasoactive intestinal peptide (VIP). | |
| | |
MedLine Citation:
|
PMID: 4062433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this study the vascular effects of VIP were studied in connection with its secretory performances in the pancreas and the liver. In anesthetized dogs pancreatic blood flow was measured parallel with measurement of bile and pancreatic secretion. VIP was injected intravenously at intervals of 1 minute in amounts of 1-2048 ng.kg-1. Striking conductance increases were observed in the pancreatic vascular beds ranging from an increase of 400% (pancreatic branch of splenic a.) to an increase of 80% (inferior pancreatic duodenal a.). Pancreatic secretion increased from 0 to 408 microliters.min-1 and bile secretion from 95 to 145 microliters.min-1. VIP has powerful vasodilating effects on pancreatic vascular beds accompanying pancreatic secretion and bile secretion. Porcine VIP and 2 synthetic VIP analogues exhibited similar hemodynamic and metabolic actions. Although a correlation between vascular and metabolic effects possibly exists, the effects of VIP on gut vessels and pancreatic secretory cells are most probably separate events: at low VIP doses increase in conductance was observed without a concomitant increased secretion. A possible role of VIP maintaining an adequate blood supply to the pancreas is discussed. |
| | |
Authors:
|
W Blitz; H J Beijer; G A Charbon |
Related Documents
:
|
6164083 - Pulmonary alveolar epithelial permeability in surgically induced hemorrhagic pancreatit... 8631393 - L-arginine and pancreatic islet blood flow in anesthetized rats. 830663 - The relationship of respiratory failure to the oxygen consumption of, lactate productio... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives internationales de pharmacodynamie et de thérapie Volume: 277 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1985 Sep |
Date Detail:
|
Created Date: 1985-12-16 Completed Date: 1985-12-16 Revised Date: 2012-01-12 |
Medline Journal Info:
|
Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
|
Languages: eng Pagination: 66-76 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / secretion Blood Pressure / drug effects Dogs Female Heart Rate / drug effects Hemodynamics / drug effects Liver / drug effects, secretion Male Pancreas / blood supply, drug effects, secretion* Regional Blood Flow / drug effects Swine Time Factors Vasoactive Intestinal Peptide / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Binding of warfarin by human albumin in the presence of a perfluorochemical blood substitute.
Next Document: Effects of a new calcium entry blocking agent, KB-944, on the membrane potential and currents of mam...