| Cholinergic modulation of enhanced vulnerability to ventricular fibrillation evoked by adrenergic stimulation in the isolated rat heart. | |
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MedLine Citation:
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PMID: 6302764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether acetylcholine could antagonize the enhanced vulnerability to ventricular fibrillation evoked by adrenergic stimulation. Epinephrine, 5 X 10(-7)M, caused an 80% reduction in the ventricular fibrillation threshold and a 130% increase in the tissue level of cAMP. Acetylcholine 1 X 10(-7)M, 5 X 10(-7)M, and 1 X 10(-6)M, reduced the epinephrine-induced fall in the ventricular fibrillation threshold by 42%, 100%, and 94%, respectively. This antifibrillatory effect of acetylcholine could not be related to tissue levels of cGMP but rather was associated with reduced tissue levels of cAMP. These results demonstrate cholinergic modulation of the epinephrine-enhanced vulnerability to ventricular fibrillation and suggest that reduced accumulation of cAMP may underlie this effect. |
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Authors:
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F T Thandroyen; L M Higginson; M G Worthington; C A Muller; L H Opie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Advances in myocardiology Volume: 3 ISSN: 0270-4056 ISO Abbreviation: Adv Myocardiol Publication Date: 1982 |
Date Detail:
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Created Date: 1983-06-23 Completed Date: 1983-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000285 Medline TA: Adv Myocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology* Animals Calcium / metabolism Cardiac Pacing, Artificial Coronary Circulation / drug effects Cyclic AMP / metabolism Cyclic GMP / metabolism Dose-Response Relationship, Drug Epinephrine / pharmacology* Heart Rate / drug effects* Heart Ventricles / drug effects* Ion Channels / drug effects Male Muridae Myocardium / metabolism Receptors, Cholinergic / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 0/Receptors, Cholinergic; 51-43-4/Epinephrine; 51-84-3/Acetylcholine; 60-92-4/Cyclic AMP; 7440-70-2/Calcium; 7665-99-8/Cyclic GMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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