Document Detail

Cholinergic mechanisms involved in the pain relieving effect of spinal cord stimulation in a model of neuropathy.
MedLine Citation:
PMID:  18472215     Owner:  NLM     Status:  MEDLINE    
The mechanisms underlying the pain relieving effect of spinal cord stimulation (SCS) on neuropathic pain remain unclear. We have previously demonstrated that suppression of tactile hypersensitivity produced by SCS may be potentiated by i.t. clonidine in a rat model of mononeuropathy. Since the analgesic effect of this drug is mediated mainly via cholinergic mechanisms, a study exploring the possible involvement of the spinal cholinergic system in SCS was undertaken. The effect of SCS was assessed with von Frey filaments in rats displaying tactile hypersensitivity after partial ligation of the sciatic nerve and both SCS-responding and non-responding as well as normal rats were subjected to microdialysis in the dorsal horn. Acetylcholine (ACh) was analyzed with HPLC before, during and after SCS. SCS produced significantly increased release of ACh in the dorsal horn in rats responding to SCS whereas the release was unaffected in the non-responding animals. Furthermore, the basal release of ACh was significantly lower in nerve lesioned than in normal rats. In another group of rats it was found that the response to SCS was completely eliminated by i.t. atropine and a muscarinic M(4) receptor antagonist while a partial attenuation was produced by M(1) and M(2) antagonists. Blocking of nicotinic receptors did not influence the SCS effect. In conclusion, the attenuating effect of SCS on pain related behavior is associated with the activation of the cholinergic system in the dorsal horn and mediated via muscarinic receptors, particularly M(4,) while nicotinic receptors appear not to be involved.
Gastón Schechtmann; Zhiyang Song; Camilla Ultenius; Björn A Meyerson; Bengt Linderoth
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-09
Journal Detail:
Title:  Pain     Volume:  139     ISSN:  1872-6623     ISO Abbreviation:  Pain     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  136-45     Citation Subset:  IM    
Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institutet and University Hospital, SE-171 76 Stockholm, Sweden.
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MeSH Terms
Cholinergic Fibers / physiology*
Disease Models, Animal*
Electric Stimulation Therapy* / methods
Neuralgia / physiopathology*,  therapy
Pain / physiopathology*,  therapy
Pain Measurement / statistics & numerical data
Pain Threshold / physiology
Rats, Sprague-Dawley
Spinal Cord / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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