Document Detail

Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats.
MedLine Citation:
PMID:  6133305     Owner:  NLM     Status:  MEDLINE    
Rats treated continuously for 4 months with haloperidol (1.4-1.6 mg/kg/day), trifluoperazine (4.5-5.1 mg/kg/day), or sulpiride (102-110 mg/kg/day), but not clozapine (23-26 mg/kg/day), exhibited an increased frequency of chewing jaw movements. Chewing in both control and haloperidol-treated rats was increased by acute administration of the cholinergic agents pilocarpine or physostigmine. Physostigmine or pilocarpine also induced abnormal gaping jaw movements; physostigmine-induced gaping was more prevalent in haloperidol-treated rats than control rats receiving physostigmine alone. Acute administration of the anticholinergic agents scopolamine and atropine decreased chewing in control animals and reduced haloperidol-induced chewing to control values or below. The effects of these cholinergic manipulations suggest that neuroleptic-induced perioral responses in rats do not resemble tardive dyskinesia in man.
N M Rupniak; P Jenner; C D Marsden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  79     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1983  
Date Detail:
Created Date:  1983-06-17     Completed Date:  1983-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
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MeSH Terms
Antipsychotic Agents / pharmacology*
Dyskinesia, Drug-Induced / physiopathology*
Parasympathetic Nervous System / physiology*
Parasympatholytics / pharmacology
Parasympathomimetics / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Antipsychotic Agents; 0/Parasympatholytics; 0/Parasympathomimetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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