| Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats. | |
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MedLine Citation:
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PMID: 6133305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats treated continuously for 4 months with haloperidol (1.4-1.6 mg/kg/day), trifluoperazine (4.5-5.1 mg/kg/day), or sulpiride (102-110 mg/kg/day), but not clozapine (23-26 mg/kg/day), exhibited an increased frequency of chewing jaw movements. Chewing in both control and haloperidol-treated rats was increased by acute administration of the cholinergic agents pilocarpine or physostigmine. Physostigmine or pilocarpine also induced abnormal gaping jaw movements; physostigmine-induced gaping was more prevalent in haloperidol-treated rats than control rats receiving physostigmine alone. Acute administration of the anticholinergic agents scopolamine and atropine decreased chewing in control animals and reduced haloperidol-induced chewing to control values or below. The effects of these cholinergic manipulations suggest that neuroleptic-induced perioral responses in rats do not resemble tardive dyskinesia in man. |
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Authors:
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N M Rupniak; P Jenner; C D Marsden |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychopharmacology Volume: 79 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1983 |
Date Detail:
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Created Date: 1983-06-17 Completed Date: 1983-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 226-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipsychotic Agents / pharmacology* Dyskinesia, Drug-Induced / physiopathology* Face Male Mouth Parasympathetic Nervous System / physiology* Parasympatholytics / pharmacology Parasympathomimetics / pharmacology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Parasympatholytics; 0/Parasympathomimetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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