Document Detail

Cholinergic and behavioral neurotoxicity of carbaryl and cadmium to larval rainbow trout (Oncorhynchus mykiss).
MedLine Citation:
PMID:  11386719     Owner:  NLM     Status:  MEDLINE    
Pesticides and heavy metals are common environmental contaminants that can cause neurotoxicity to aquatic organisms, impairing reproduction and survival. Neurotoxic effects of cadmium and carbaryl exposures were estimated in larval rainbow trout (RBT; Oncorhynchus mykiss) using changes in physiological endpoints and correlations with behavioral responses. Following exposures, RBT were videotaped to assess swimming speed. Brain tissue was used to measure cholinesterase (ChE) activity, muscarinic cholinergic receptor (MChR) number, and MChR affinity. ChE activity decreased with increasing concentrations of carbaryl but not of cadmium. MChR were not affected by exposure to either carbaryl or cadmium. Swimming speed correlated with ChE activity in carbaryl-exposed RBT, but no correlation occurred in cadmium-exposed fish. Thus, carbaryl exposure resulted in neurotoxicity reflected by changes in physiological and behavioral parameters measured, while cadmium exposure did not. Correlations between behavior and physiology provide a useful assessment of neurotoxicity.
S L Beauvais; S B Jones; J T Parris; S K Brewer; E E Little
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  49     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-01     Completed Date:  2001-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Columbia Environmental Research Center, USGS/BRD, Columbia, Missouri 65201, USA.
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MeSH Terms
Brain / enzymology
Cadmium / adverse effects*
Carbaryl / adverse effects*
Cholinesterases / analysis
Insecticides / adverse effects*
Nervous System / drug effects
Oncorhynchus mykiss / physiology*
Receptors, Muscarinic / drug effects,  physiology
Toxicity Tests
Water Pollutants, Chemical / adverse effects*
Reg. No./Substance:
0/Insecticides; 0/Receptors, Muscarinic; 0/Water Pollutants, Chemical; 63-25-2/Carbaryl; 7440-43-9/Cadmium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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