| Cholinergic agents in the laryngeal chemoreflex model of sudden infant death syndrome. | |
| | |
MedLine Citation:
|
PMID: 8502096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The laryngeal chemoreflex results in apnea, laryngospasm, and cardiovascular changes that can be fatal when a liquid stimulus is placed on the laryngeal mucosa of infant mammals. This study of 35 piglets assessed the effects of the cholinergic agents atropine and edrophonium on this laryngeal reflex response. Atropine, when placed intrathecally, resulted in a significant reduction of apnea as well as a decrease in the cardiovascular changes that occur during the reflex 60 minutes following its injection. Edrophonium, when placed intrathecally, resulted in a significant prolongation of apnea as well as death by asystole in 2 animals during laryngeal stimulation. Atropine placed intravenously also resulted in a significant reduction of apnea length, but required greater than 180 minutes to do so. |
| | |
Authors:
|
F Rimell; G S Goding; K Johnson |
Related Documents
:
|
7858696 - Access to home apnea monitoring and its impact on rehospitalization among very-low-birt... 12621096 - Circadian and sleep development in preterm infants occurs independently from the influe... 10568416 - Nonvagal tachypnea following alpha2-adrenoceptor stimulation in awake goats. 7353966 - Intercostal muscle reflexes and sleep breathing patterns in the human infant. 657056 - Effectiveness of neonatal transport. 3900836 - Cohort study of silastic obstetric vacuum cup deliveries: i. safety of the instrument. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Laryngoscope Volume: 103 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 1993 Jun |
Date Detail:
|
Created Date: 1993-06-30 Completed Date: 1993-06-30 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 623-30 Citation Subset: IM |
Affiliation:
|
Department of Otolaryngology, University of Minnesota, Minneapolis. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn Apnea / physiopathology Atropine / pharmacology* Blood Pressure / drug effects Chemoreceptor Cells / drug effects* Disease Models, Animal Edrophonium / pharmacology* Electromyography Heart Rate / drug effects Humans Laryngeal Nerves / drug effects* Male Reflex / drug effects* Respiration / drug effects Sudden Infant Death* Swine |
| Chemical | |
Reg. No./Substance:
|
312-48-1/Edrophonium; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of two methods of tonsillectomy.
Next Document: Use of the holmium: yttrium aluminum garnet (Ho:YAG) laser for cranial nerve decompression: an in vi...