Document Detail

Cholinergic agents in the laryngeal chemoreflex model of sudden infant death syndrome.
MedLine Citation:
PMID:  8502096     Owner:  NLM     Status:  MEDLINE    
The laryngeal chemoreflex results in apnea, laryngospasm, and cardiovascular changes that can be fatal when a liquid stimulus is placed on the laryngeal mucosa of infant mammals. This study of 35 piglets assessed the effects of the cholinergic agents atropine and edrophonium on this laryngeal reflex response. Atropine, when placed intrathecally, resulted in a significant reduction of apnea as well as a decrease in the cardiovascular changes that occur during the reflex 60 minutes following its injection. Edrophonium, when placed intrathecally, resulted in a significant prolongation of apnea as well as death by asystole in 2 animals during laryngeal stimulation. Atropine placed intravenously also resulted in a significant reduction of apnea length, but required greater than 180 minutes to do so.
F Rimell; G S Goding; K Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  103     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-30     Completed Date:  1993-06-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  623-30     Citation Subset:  IM    
Department of Otolaryngology, University of Minnesota, Minneapolis.
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MeSH Terms
Animals, Newborn
Apnea / physiopathology
Atropine / pharmacology*
Blood Pressure / drug effects
Chemoreceptor Cells / drug effects*
Disease Models, Animal
Edrophonium / pharmacology*
Heart Rate / drug effects
Laryngeal Nerves / drug effects*
Reflex / drug effects*
Respiration / drug effects
Sudden Infant Death*
Reg. No./Substance:
312-48-1/Edrophonium; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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