Document Detail

Cholinergic control of the cerebral vasculature in humans.
MedLine Citation:
PMID:  23070700     Owner:  NLM     Status:  MEDLINE    
Despite growing evidence of autonomic nervous system involvement in the regulation of cerebral blood flow, the specific contribution of cholinergic vasodilatation to cerebral autoregulation remains unknown. We examined cerebral and forearm blood flow responses to augmented arterial pressure oscillations with and without cholinergic blockade. Oscillatory lower body negative pressure was applied at six frequencies from 0.03 to 0.08 Hz in nine healthy subjects with and without cholinergic blockade via glycopyrrolate. Cholinergic blockade increased cross-spectral coherence between arterial pressure and cerebral flow at all frequencies except 0.03 Hz and increased the transfer function gain at frequencies above 0.05 Hz. In contrast, gain between pressure and forearm flow increased only at frequencies below 0.06 Hz. These data demonstrate that the cholinergic system plays an active and unique role in cerebral autoregulation. The frequency region and magnitude of effect is very similar to what has been seen with sympathetic blockade, indicating a possible balance between the two reflexes to most effectively respond to rising and falling pressure. These findings might have implications for the role of dysfunction in autonomic control of the vasculature in cerebrovascular disease states.
J W Hamner; Can Ozan Tan; Yu-Chieh Tzeng; J Andrew Taylor
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-15
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-06-13     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6343-52     Citation Subset:  IM    
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MeSH Terms
Arterial Pressure
Blood Flow Velocity / drug effects
Cerebrovascular Circulation / drug effects*
Cholinergic Fibers / drug effects*
Forearm / blood supply*
Glycopyrrolate / pharmacology*
Heart Rate / drug effects
Lower Body Negative Pressure
Middle Cerebral Artery / drug effects*,  innervation,  ultrasonography
Muscarinic Antagonists / pharmacology*
Regional Blood Flow / drug effects
Time Factors
Ultrasonography, Doppler, Transcranial
Young Adult
Grant Support
Reg. No./Substance:
0/Muscarinic Antagonists; V92SO9WP2I/Glycopyrrolate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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