Document Detail


Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
MedLine Citation:
PMID:  23298754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system. Animal studies have shown that choline status pre- and postnatally can have long-lasting effects on attention and memory; however, effects in human subjects have not been well studied. The aim of the present study was to examine the association between plasma concentrations of free choline and its related metabolites in children and their neurodevelopment in the Seychelles Child Development Nutrition Study, an ongoing longitudinal study assessing the development of children born to mothers with high fish consumption during pregnancy. Plasma concentrations of free choline, betaine, dimethylglycine (DMG), methionine and homocysteine and specific measures of neurodevelopment were measured in 210 children aged 5 years. The children's plasma free choline concentration (9·17 (sd 2·09) μmol/l) was moderately, but significantly, correlated with betaine (r 0·24; P= 0·0006), DMG (r 0·15; P= 0·03), methionine (r 0·24; P= 0·0005) and homocysteine (r 0·19; P= 0·006) concentrations. Adjusted multiple linear regression revealed that betaine concentrations were positively associated with Preschool Language Scale – total language scores (β = 0·066; P= 0·04), but no other associations were evident. We found no indication that free choline concentration or its metabolites, within the normal physiological range, are associated with neurodevelopmental outcomes in children at 5 years of age. As there is considerable animal evidence suggesting that choline status during development is associated with cognitive outcome, the issue deserves further study in other cohorts.
Authors:
J J Strain; Emeir M McSorley; Edwin van Wijngaarden; Roni W Kobrosly; Maxine P Bonham; Maria S Mulhern; Alison J McAfee; Philip W Davidson; Conrad F Shamlaye; Juliette Henderson; Gene E Watson; Sally W Thurston; Julie M W Wallace; Per M Ueland; Gary J Myers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-09
Journal Detail:
Title:  The British journal of nutrition     Volume:  110     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  2013-08-26     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  330-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Betaine / blood*
Child Development*
Child, Preschool
Choline / blood*,  metabolism
Cognition*
Female
Homocysteine / blood
Humans
Language*
Linear Models
Longitudinal Studies
Male
Methionine / blood
Neuropsychological Tests
Nutritional Status*
Pregnancy
Sarcosine / analogs & derivatives,  blood
Seychelles
Grant Support
ID/Acronym/Agency:
P30 ES001247/ES/NIEHS NIH HHS; P30-ES001247/ES/NIEHS NIH HHS; R01 ES008442/ES/NIEHS NIH HHS; R01 ES010219/ES/NIEHS NIH HHS; R01 ES015578/ES/NIEHS NIH HHS; R01-ES010219/ES/NIEHS NIH HHS; R01-ES015578/ES/NIEHS NIH HHS; T32 ES007271/ES/NIEHS NIH HHS; T32-ES007271/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0LVT1QZ0BA/Homocysteine; 3SCV180C9W/Betaine; 7797M4CPPA/dimethylglycine; AE28F7PNPL/Methionine; N91BDP6H0X/Choline; Z711V88R5F/Sarcosine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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