Document Detail


Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.
MedLine Citation:
PMID:  20534746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Choline is essential for infant nutrition, and breast milk is a rich source of this nutrient. Common single nucleotide polymorphisms (SNPs) change dietary requirements for choline intake.
OBJECTIVE: The aim of this study was to determine whether total choline intake and/or SNPs influence concentrations of choline and its metabolites in human breast milk and plasma.
DESIGN: We gave a total of 103 pregnant women supplemental choline or a placebo from 18 wk gestation to 45 d postpartum and genotyped the women for 370 common SNPs. At 45 d postpartum, we measured choline metabolite concentrations in breast milk and plasma and assessed the dietary intake of choline by using a 3-d food record.
RESULTS: On average, lactating women in our study ate two-thirds of the recommended intake for choline (Adequate Intake = 550 mg choline/d). Dietary choline intake (no supplement) correlated with breast-milk phosphatidylcholine and plasma choline concentrations. A supplement further increased breast-milk choline, betaine, and phosphocholine concentrations and increased plasma choline and betaine concentrations. We identified 5 SNPs in MTHFR that altered the slope of the intake-metabolite concentration relations, and we identified 2 SNPs in PEMT that shifted these curves upward. Individuals who shared sets of common SNPs were outliers in plots of intake-metabolite concentration curves; we suggest that these SNPs should be further investigated to determine how they alter choline metabolism.
CONCLUSION: Total intake of choline and genotype can influence the concentrations of choline and its metabolites in the breast milk and blood of lactating women and thereby affect the amount of choline available to the developing infant. This study was registered at clinicaltrials.gov as NCT00678925.
Authors:
Leslie M Fischer; Kerry Ann da Costa; Joseph Galanko; Wei Sha; Brigitte Stephenson; Julie Vick; Steven H Zeisel
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-06-09
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-12     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-46     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00678925
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MeSH Terms
Descriptor/Qualifier:
Adult
Betaine / analysis,  blood
Choline / administration & dosage,  analysis,  metabolism*
Diet
Diet Records
Dietary Supplements
Female
Genotype
Humans
Lactation
Maternal Nutritional Physiological Phenomena
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Milk, Human / chemistry*
Nutrition Policy
Phosphatidylcholines / analysis
Phosphatidylethanolamine N-Methyltransferase / genetics*
Phosphorylcholine / analysis
Polymorphism, Single Nucleotide*
Pregnancy / blood,  genetics
Young Adult
Grant Support
ID/Acronym/Agency:
AG09525/AG/NIA NIH HHS; DK034987/DK/NIDDK NIH HHS; DK55865/DK/NIDDK NIH HHS; DK56350/DK/NIDDK NIH HHS; P30 ES010126/ES/NIEHS NIH HHS; RR00046/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 107-73-3/Phosphorylcholine; 3SCV180C9W/Betaine; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2); EC 2.1.1.17/PEMT protein, human; EC 2.1.1.17/Phosphatidylethanolamine N-Methyltransferase; N91BDP6H0X/Choline
Comments/Corrections

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