| Choline in anxiety and depression: the Hordaland Health Study. | |
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MedLine Citation:
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PMID: 19656836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Despite its importance in the central nervous system as a precursor for acetylcholine and membrane phosphatidylcholine, the role of choline in mental illness has been little studied. OBJECTIVE: We examined the cross-sectional association between plasma choline concentrations and scores of anxiety and depression symptoms in a general population sample. DESIGN: We studied a subsample (n = 5918) of the Hordaland Health Study, including both sexes and 2 age groups of 46-49 and 70-74 y who had valid information on plasma choline concentrations and symptoms of anxiety and depression measured by the Hospital Anxiety and Depression Scale--the latter 2 as continuous measures and dichotomized at a score > or =8 for both subscales. RESULTS: The lowest choline quintile was significantly associated with high anxiety levels (odds ratio: 1.33; 95% CI: 1.06, 1.69) in the fully adjusted (age group, sex, time since last meal, educational level, and smoking habits) logistic regression model. Also, the trend test in the anxiety model was significant (P = 0.007). In the equivalent fully adjusted linear regression model, a significant inverse association was found between choline quintiles and anxiety levels (standardized regression coefficient = -0.027, P = 0.045). We found no significant associations in the corresponding analyses of the relation between plasma choline and depression symptoms. CONCLUSION: In this large population-based study, choline concentrations were negatively associated with anxiety symptoms but not with depression symptoms. |
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Authors:
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Ingvar Bjelland; Grethe S Tell; Stein E Vollset; Svetlana Konstantinova; Per M Ueland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-05 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 90 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2009-10-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1056-60 Citation Subset: AIM; IM |
Affiliation:
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Department of Child and Adolescent Psychiatry, Haukeland University Hospital, Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anxiety / blood*, epidemiology Choline / blood* Cross-Sectional Studies Depression / blood*, epidemiology Dose-Response Relationship, Drug Female Humans Logistic Models Male Middle Aged Norway |
| Chemical | |
Reg. No./Substance:
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62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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