Document Detail


Choline acetyltransferase activity parallels the pressure gradient in the feline pharyngo-esophageal region.
MedLine Citation:
PMID:  11474640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pressures generated by the pharyngeal constrictor muscles and proximal esophagus involve acetylcholine-induced muscle contractions. We hypothesized that the pharyngo-esophageal pressure gradient is related to choline acetyltransferase activity. In nine anesthetized cats, hypopharyngeal pressure and proximal esophageal pressure were recorded with a solid state transducer assembly. Enzymatic activities in the thyropharyngeus, cricopharyngeus, and proximal esophageal muscles were measured. Hypopharyngeal pressure was higher than the proximal esophagus (p < 0.01), and choline acetyltransferase activity was higher in the cricopharyngeus compared to the proximal esophagus ( p < 0.05). The pressure gradient between the hypopharynx and proximal esophagus may be influenced by the activity of choline acetyltransferase.
Authors:
P Xie; B Medda; J Ren; E Mustin; R Shaker; T R Koch
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  89     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-04     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  125-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Medical College of Wisconsin, Zablocki VA Medical Center, Milwaukee 53295, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / metabolism
Animals
Cats
Choline O-Acetyltransferase / metabolism*
Deglutition / physiology
Esophagus / innervation*,  physiology
Pharynx / innervation*,  physiology
Pressure
Vagus Nerve / enzymology*,  physiology
Grant Support
ID/Acronym/Agency:
P01 DC03191/DC/NIDCD NIH HHS; R01 DK25731/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
EC 2.3.1.6/Choline O-Acetyltransferase; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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