| Choline acetyltransferase activity and [3H]vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions. | |
| | |
MedLine Citation:
|
PMID: 2166243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
[3H]Vesamicol binding was characterized in human brain post mortem. The number of binding sites was then determined in parallel with choline acetyltransferase activity in the temporal cortex of patients with Alzheimer's disease, demented and non-demented patients with Parkinson's disease, and in the cerebral cortex of rats with quisqualic acid lesions of the nucleus basalis magnocellularis. Whereas choline acetyltransferase activity decreased in patients with Alzheimer's or Parkinson's disease indicating loss of cholinergic innervation, the number of binding sites for [3H]vesamicol was the same as or higher than in controls. Similar results were obtained with the lesioned rats. It is suggested that the increase in binding sites may reflect compensatory regulation of the spared neurons at the level of the synaptic vesicle. |
| | |
Authors:
|
M Ruberg; W Mayo; A Brice; C Duyckaerts; J J Hauw; H Simon; M LeMoal; Y Agid |
Related Documents
:
|
150253 - Huntington disease associated with alzheimer disease. 15681623 - Diffusion tensor imaging of frontal white matter microstructure in early alzheimer's di... 22622203 - Transoral incisionless fundoplication with esophyx(®) for treatment of gastro-oesphage... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neuroscience Volume: 35 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-09-11 Completed Date: 1990-09-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 327-33 Citation Subset: IM |
Affiliation:
|
INSERM U. 289, Hôpital de la Salpêtrière, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Alzheimer Disease / metabolism*, physiopathology Animals Brain Injuries / chemically induced, metabolism* Choline O-Acetyltransferase / metabolism* Female Humans Hydroxydopamines Kinetics Male Neuromuscular Depolarizing Agents / metabolism Oxadiazoles Oxidopamine Parkinson Disease / metabolism* Phencyclidine / analogs & derivatives*, metabolism Piperidines* Quisqualic Acid Rats Rats, Inbred Strains Receptors, Neurotransmitter / metabolism* Receptors, Phencyclidine Reference Values Substantia Nigra / metabolism Temporal Lobe / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Hydroxydopamines; 0/Neuromuscular Depolarizing Agents; 0/Oxadiazoles; 0/Piperidines; 0/Receptors, Neurotransmitter; 0/Receptors, Phencyclidine; 1199-18-4/Oxidopamine; 22232-64-0/vesamicol; 52809-07-1/Quisqualic Acid; 77-10-1/Phencyclidine; EC 2.3.1.6/Choline O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: N-methyl-D-aspartate receptors mediate activation of the c-fos proto-oncogene in a model of brain in...
Next Document: Decrease in hippocampal [3H]vinylidene kainic acid binding in genetically epilepsy-prone rats.