Document Detail


Cholic acid-based fluorescent probes for enantioselective recognition of trifunctional amino acids.
MedLine Citation:
PMID:  18292886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ditopic fluorescent photoinduced electron transfer (PET) amino acid sensory probes and were designed and synthesized from cholic acid. To confer the probes with specific binding ability, an amidothiourea moiety and a cyclic diamino-chiral receptive site were introduced on the C17 side chain and the C7 and C12 hydroxyl pendants, respectively. In acetonitrile, the probes demonstrated differential binding toward trifunctional amino acids like serine, lysine, threonine and tyrosine against other simple amino acids. Enantioselectivities (KD/KL) of up to 8.9 and sensitivities in the micromolar range with the probes were observed for trifunctional amino acids.
Authors:
Hao Wang; Wing-Hong Chan; Albert W M Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-31
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  6     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-22     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  929-34     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Binding Sites
Cholic Acid / chemistry*
Fluorescent Dyes / chemical synthesis,  chemistry*
Hydrogen Bonding
Molecular Conformation
Sensitivity and Specificity
Stereoisomerism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Fluorescent Dyes; 81-25-4/Cholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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